Table 4: Classification of Allergic and Pseudoallergic Reactions to ASA and NSAIDs. Adapted from Stevenson D, Sanchez-Borges M, Szczeklik A. Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes. Ann Allergy 2001;98:177-180 .
Description of reactions |
Underlying Disease |
Cross-reactions First Exposure |
Current Terminology |
NSAID-induced rhinitis and asthma |
Asthma/Nasal polyps/sinusitis |
Yes |
Intolerance, ASA-induced, Sensitivity |
NSAID-induced urticaria/angioedema |
Chronic idiopathic urticaria |
Yes |
Acute/chronic urticaria, angioedema |
Single drug-induced urticaria/angioedema |
None |
No |
Acute urticaria/angioedema |
Multiple drug-induced urticaria/angioedema |
None |
Yes |
Acute urticaria |
Single drug-induced anaphylaxis |
None |
No |
Anaphylactoid |
Single drug or NSAID-induced blended reaction |
Asthma, rhinitis, uriticaria, or none |
No or Yes |
Asthma and urticaria |