Table 3: Skin testing with major and minor determinants . Adapted from Sogn D, Evans RE, Shepherd G, Casale T, Condemi J, Greenberger P, et al. Results of the National Institute of Allergy and Infectious Diseases Collaborative Clinical Trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults. Arch Intern Med 1992;152:1025-32.
Major Determinant Skin Test |
Minor Determinant Skin Test |
Risk of Anaphylaxis |
POSITIVE |
NEGATIVE |
60% |
NEGATIVE |
POSITIVE |
60% |
POSITIVE |
POSITIVE |
>60% |
NEGATIVE |
NEGATIVE |
<2% |