Table 2: Classification of Immune Mediated Adverse Drug Reactions . Adapted from Adkinson NF . Drug Allergy. In Middleton's Allergy: Principles and Practice, 6 th edition. New York : Mosby 2003. p. 1679-94, table 92-3.
Gel-Coombs Classification |
Mechanism |
Examples of Adverse Penicillin Reactions |
Other medication examples |
|
I |
Anaphylactic (IgE-mediated injury) |
Acute anaphylaxis Urticaria |
|
|
II |
C'-dependent cytolysis (IgG/IgM) |
Hemolytic anemias |
Quinidine, alpha-methyldopa |
|
|
|
Thrombocytopenia |
|
|
|
|
Interstitial nephritis |
NSAIDs |
|
III |
Immune complex damage |
Serum sickness |
Murine monoclonal antibodies |
|
|
|
Drug fever |
|
|
|
|
Some cutaneous eruptions and vasculitis |
|
|
IV |
“Delayed” or cellular hypersensitivity |
Contact dermatitis |
Topical drugs |
|
|
|
Morbilliform eruptions |
|
|
C, Complement. |
|
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