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Brian Zamarron
e-mail address: zamarrbf@umich.edu

Mentor: Carey Lumeng, MD, PhD


Research Description


Obesity is now known to generate a state of chronic low-grade inflammation.  Importantly, many of the negative health effects of obesity, such as metabolic syndrome and type 2 diabetes, are related to this inflammation.  Adipose tissue itself contains a number of immune cells, and obesity is associated with the accumulation and activation of macrophages and Th1 lymphocytes within this tissue.  Relatively little is known about how these cells interact and, ultimately, what influence this interaction has on disease and immunity.  Research is focused on studying the mechanisms by which adipose tissue macrophages shift from an M2 to an M1 state and how this relates to T cell activation and suppression in adipose tissue with obesity.


Publications

Research Articles

Li, J., Maruyama, T., Zhang, P., Konkel, J., Hoffmann, V., Zamarron, BF., & Chen, W. Mutation of inhibitory helix-loop-helix protein Id3 causes γδT-cell lymphoma in mice. Blood. December 2010; 116(25):5615-21.
PMCID: PMC3031408

Maruyama, T., Li, J., Vaque, J. P., Konkel, J., Wang, W., Zhang, B., Zhang, P., Zamarron, BF., Yu D., Wu, Y., Zhuang, Y., Gutkind, J. S., & Chen, W.  Control of regulatory T cell and Th17 cell differentiation by inhibitory helix-loop-helix protein Id3. Nature Immunology. January 2011; 12(1):86-95. PMCID: PMC3140164

Konkel, JE., Maruyama, T., Carpenter AC., Xiong Y., Zamarron, BF., Hall BE., Kulkarni, A., Zhang, P., Bosselut R., & Chen, W.  Control of CD8αα intestinal intraepithelial lymphocyte development by transforming growth factor-beta. Nature Immunology. April 2011; 12(4):312-9. PMCID: PMC3062738

Zhang, P., Maruyama, T., Konkel J., Abbatiello B., Zamarron, B., Wang, ZQ., Chen, W. PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3. PLOS One. August 2013; 8(8):e71590.
PMCID: PMC3747222

W O'Rourke, R; Meyer, KA; Neeley, CK; Gaston, GD; Sekhri, P; Szumowski, M; Zamarron, B; Lumeng, CN; Marks, DL. Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity. Obesity. June 2014. PMID:  24962029

Kanakadurga Singer, Jennifer DelProposto, David Lee Morris, Brian Zamarron, Taleen Mergian, Nidhi Maley, Kae Won Cho, Lynn Geletka, Perla Subbaiah, Lindsey Muir, Gabriel Martinez-Santibanez, Carey Nien-Kai Lumeng. Diet-induced Obesity Promotes Myelopoiesis in Hematopoietic Stem Cells. In Press Molecular Metabolism

Kae Won Cho, David L. Morris, Jennifer L. DelProposto, Lynn Geletka, Brian Zamarron, Kevin A. Meyer, Kanakadurga Singer, Robert W. O’Rourke and Carey N. Lumeng. An MHC Class II Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T cells Controls Obesity-Induced Inflammation. Accepted Cell Reports


Review Articles

Zamarron, BF & Chen, W.  Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Int J Biol Sci. May 2011; 7(5):651-658. PMCID: PMC3107473

Maruyama, T., Konkel, JE., Zamarron, BF., Chen, W. The Molecular Mechanisms of Foxp3 Gene Regulation. Seminars in Immunology. December 2011;23(6):418-423. PMCID: PMC3205321



Awards

Ruth L. Kirschstein National Research Service Award – National Institutes of Health 2014-2017

Pre-doctoral fellowship – American Heart Association 2014-2016

Basic and Translational Digestive Sciences Training Grant Funding 2013-2014

International Journal of Biological Sciences Most Cited Paper Award 2013

National Institutes of Health Intramural Research Training Award 2009-2011

Rackham Merit Fellowship, 2011


 



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