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Timothy Welliver Mentor: Joel Swanson, PhD
Research Description Our lab is working to elucidate the mechanisms underlying phagocytosis and macropinocytosis. Specifically, we seek to identify the patterns of temporal and spatial activation of Rho GTPases during these ingestive processes. Our work relies heavily on FRET and Confocal microscopy.
Reed J.L., Welliver T.P., Sims G.P., McKinney L., Velozo L., Avendano L., Hintz K., Luma J., Coyle A.J., and Welliver R.C. Innate Immune Signals Modulate Antiviral and Polyreactive Antibody Responses during Severe Respiratory Syncytial Virus Infection. J Infect Dis. 2009 Apr 15;199(8):1128-38. Cover. Reed J.L., Brewah Y.A., Kuta E., Ready S., Welliver T., Delaney T., Benjamin E., Rutt B., Burwell T.J., McKinney L., Avendano L., Velozo L., Welliver R.C., Kiener P.A., Humbles A.A., Coyle A. J. Central role macrophages and type I interferon in primary respiratory syncytial virus bronchiolitis. J Infect Dis. 2008 Dec 15;198(12):1783-93. Cover. Welliver T.P., Reed J.L., Welliver R.C. Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases. Pediatr Infect Dis J. 2008 Oct;27(10 Suppl):S92-6. Welliver T.P., Garofalo R.P., Hintz K.H., Avendano L., Sanchez K., Velozo L., Jafri H., Chavez-Bueno S., Ogra P.L., McKinney L., Reed J.L., and Welliver R.C. Severe viral bronchiolitis in human infants is characterized by the absence of cytotoxic T lymphocyte responses in the lung. J Infect Dis. 2007 Apr 15;195(8): 1126-1136. Cover and commentary.Reed J.L., Brewah Y.A., Kuta E., Ready S., Welliver T., Delaney T., Benjamin E., Rutt B., Burwell T.J., McKinney L., Avendano L., Velozo L., Welliver R.C., Kiener P.A., Humbles A.A., Coyle A. J. Central role macrophages and type I interferon in primary respiratory syncytial virus bronchiolitis. Accepted: J. Infect. Dis, March 2007.
Abstracts Reed, J.L., Brewah Y.A., Delaney T., Welliver T., Burwell T.J., Benjamin E., Kuta E., Kozhich A., McKinney L, Suzich J., Kiener P.A., Avendano L., Velozo L., Humbles A.A., R. C. Welliver, Sr., and Coyle A.J.: Macrophage insufficiency underlies type I interferon mediated apoptotic crisis in RSV Bronchiolitis. RSV Symposium, Marco Island, FL, October 26, 2007. Reed J.L., Sims G., Welliver T., McKinney L., Avendano L., Velozo L, Coyle A.J., and Welliver R.C. T lymphocyte independent antibody responses in primary RSV infection. RSV Symposium, Marco Island , FL, October 26, 2007. Welliver, T., Reed J.L., Coyle A.J., and Welliver R.C. Antibody responses in primary RSV bronchiolitis are T lymphocyte independent. American Thoracic Society International Meeting, San Francisco. May 23, 2007. Reed JL, Brewah YA, Delaney T, Welliver T, Benjamin E, Kozhich AT, McKinney L, Burwell TJ, Kiener PA, Humbles AA, Coyle AJ. Proinflammatory Effects of Type I Interferon Exacerbate Primary RSV Disease in Susceptible NZB Mice. American Thoracic Society International Meeting, San Francisco. May 18, 2007.
Awards MAAS Deans Fellowship
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