Mentor: David Fox, M.D.
I am working on the role of CD13/Aminopeptidase N in Rheumatoid Arthritis (RA). Specifically I measure the amount and activity of CD13 in biological samples from RA individuals. I look at the localization of CD13 on fibroblast like synoviocytes (FLS) both cellular and extracellular. I’m also working to determine how CD13 (normally a cell surface molecule) becomes soluble. I also look at the regulation of CD13 by pro-inflammatory factors on RA FLS. In addition I’m exploring possible functions for CD13 in RA disease pathogenicity. My main focus is on CD13 as a pro-migratory agent for FLS and T cells. Especially how CD13 could aid T cells in entering an RA joint.
Fox DA, Gizinski A, Morgan R, Lundy SK. Cell-cell interactions in rheumatoid arthritis synovium. Rheum Dis Clin North Am. 2010 May;36(2):311-23. PMID: 20510236.
R Morgan; N Behbahani-Nejad; J Endres; D Fox. “Aminopeptidase N/CD13 Expression by FLS and T Cell Chemotaxis.” Rheumatoid Arthritis: Molecular and Clinical Insights Keystone Symposium, January 2012, Santa Fe, New Mexico.
Rachel Morgan, Nilofar Behbahani-Nejad,Judith Endres, and David A.Fox. "Aminopeptidase N/CD13 Localization and Chemotaxis in Rheumatoid Arthritis In Vivo and In Vitro." American College of Rheumatology Annual Meeting, November 2011, Chicago, IL.
Monte V Hobbs Immunology Award, 2011