e-mail address: email@example.com
David Fox, M.D.
I am working on the role of CD13/Aminopeptidase N in Rheumatoid Arthritis (RA). Specifically I measure the amount and activity of CD13 in biological samples from RA individuals. I look at the localization of CD13 on fibroblast like synoviocytes (FLS) both cellular and extracellular. I’m also working to determine how CD13 (normally a cell surface molecule) becomes soluble. I also look at the regulation of CD13 by pro-inflammatory factors on RA FLS. In addition I’m exploring possible functions for CD13 in RA disease pathogenicity. My main focus is on CD13 as a pro-migratory agent for FLS and T cells. Especially how CD13 could aid T cells in entering an RA joint.
Morgan R, Endres J, Behbahani-Nejad N, Phillips K, Ruth JH, Friday SC, Edhayan G, Lanigan T, Urquhart A, Chung KC, Fox DA. Expression and Function of Aminopeptidase N/CD13 Produced by Fibroblast Like Synoviocytes in Rheumatoid Arthritis: Role of CD13 in Chemotaxis of Cytokine Activated T cells Independent of Enzymatic Activity.Arthritis Rheumatol. 2014 Sep 12. doi: 10.1002/art.38878. [Epub ahead of print]
Kitko Carrie L, John E Levine, Varry E Storer, Xiaoyu Chai, David A Fox, Thomas M Braun, Daniel R Couriel, Paul J Martin, Mary E Flowers, John A Hansen, Lawrence Chang, Megan Conlon, Bryan J Fiema, Rachel Morgan Prae Pongtornpipat, Kelly Lamiman, James LM Ferrara, Stephanie J Lee, Sophie Paczesny. Plasma CXCL9 elevations correlate with chronic GVHD diagnosis. Blood. 2014 Jan; 123 (5): 786-793.
Fox DA, Gizinski A, Morgan R, Lundy SK. Cell-cell interactions in rheumatoid arthritis synovium. Rheum Dis Clin North Am. 2010 May;36(2):311-23. PMID: 20510236.
Downing B, Morgan R, VanHulle K, Deem A, Malkova A. Large inverted repeats in the vicinity of a single double-strand break strongly affect repair in yeast diploids lacking Rad51. Mutat Res. 2008 Oct 14;645(1-2):9-18. Epub 2008 Aug 5
Morgan, Rachel; Fox, David A. MD; Behbahani-Nejad, Nilofar; Endres, Judith
"Functions Of Aminopeptidase N/CD13 In Vitro On Rheumatoid Arthritis Synovial Cells" American College of Rheumatology Meeting, October 2013, San Diego, CA.
R Morgan; N Behbahani-Nejad; J Endres; D Fox. “Aminopeptidase N/CD13 Expression by FLS and T Cell Chemotaxis.” Rheumatoid Arthritis: Molecular and Clinical Insights Keystone Symposium, January 2012, Santa Fe, New Mexico. Poster.
Rachel Morgan, Nilofar Behbahani-Nejad,Judith Endres, and David A.Fox. "Aminopeptidase N/CD13 Localization and Chemotaxis in Rheumatoid Arthritis In Vivo and In Vitro." American College of Rheumatology Annual Meeting, November 2011, Chicago, IL. Oral Presentation
Rachel Morgan, Judith Endres, and David Fox “Functional Expression of CD13/Aminopeptidase N by RA Synovial Cells In Vitro and In Vivo.” University of Michigan Internal Medicine Research Symposium, Ann Arbor, MI. May 2011. Oral Presentation
Rachel Morgan, Judith Endres, and David Fox “Functional Expression of CD13/Aminopeptidase N by RA Synovial Cells In Vitro and In Vivo.” American College of Rheumatology Annual Meeting, Atlanta, GA. October 2010.
Rackham Predoctoral Travel Grant, 2013
Abraham H. Grant Scholastic Grant Award 2012
Keystone Symposia Travel Award 2012
Monte V Hobbs Immunology Award, 2011
ACR REF/Abbott Medical and Graduate Student Achievement Award, 2011
Rackham Predoctoral Travel Grant, 2010
Rackham Merit Fellowship, 2007