Jennifer Oliver
e-mail address: jmoreno@umich.edu

Mentor: Philip King, PhD

Research Description:

T cell-specific adapter protein (TSAd) has been demonstrated to be important in immune signaling and modulation. Mice deficient in this molecule present diminished IL-2 production and an age-dependent lupus-like systemic autoimmune disease. I am currently investigating further the role of TSAd in T-cell activation and effector function, specifically its role in lipid rafts following activation through the TCR.

Publications:

Ratner S, Wei WZ, Oliver J, Oliver J . Enhancement of T cell localization in mammary tumors through transient inhibition of T cell myosin function. Cell Immunol. 2005, 233 (1): 1-10.

Williams LK, Oliver J , Peterson EL, Bobbitt KR, McCabe MJ, Smolarek D, Havstad SL, Wegienka G, Burchard E, Ownby DR, Johnson CC. Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3- CD4+ lymphocyte numbers and total serum IgE in early childhood. Submitted 2007.

Tran CN, Thacker SG, Louie DM, White PT, Endres JL, Oliver J , Urquhart AG, Chung KC, Fox DA . Interactions of T cells with Fibroblast-Like Synoviocytes: Role of the B7 Family Costimulatory Ligand B7-H3. Submitted 2007.