Philip Lapinski
e-mail address: philipel@umich.edu

Mentor: Philip King, PhD

Research Description

I am interested in the function of p120 RasGAP, a negative regulator of the small G-protein Ras. To study this protein, we have generated conditional RasGAP-deficient mice. I am currently studying the role of RasGAP in the function of T cells and the lymphatic system.



Publications

Lapinski PE, Kamen LA, Hughes ED, Saunders TL and King PD.Genetic analysis of SH2D4A, a novel adapter protein related to TSAd and ALX, reveals a redundant function in T cells. J. Immunol. J Immunol. 2008 Aug 1;181 (3): 2019-27.

Lapinski PE, Bauler TJ, Brown EJ, Hughes ED, Saunders TL, and King
PD. Generation of Mice with a Conditional Allele of the p120 Ras GTPase-activating Protein (RasGAP). Genesis. 2007 Dec; 45 (12): 762-7.

Marti F,. Garcia GG, Lapinski PE, MacGregor JN, and King PD.
Essential role of the T cell specific adapter protein in the activation of LCK in peripheral T cells. J. Exp. Med, 203: 2006 Feb 20; 203 (2): 281-7.

PE Lapinski, JN MacGregor, F Marti, and PD King. The T cell-specific adapter protein functions as a regulator of peripheral but not central immunological tolerance. Adv Exp Med Biol, Jan 2006; 584: 73-87.

F Marti, PE Lapinski, and PD King. The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man. Immunol Lett, Mar 2005; 97(2): 165-70.

Marti F, Lapinski PE, King PD. Sh2d2a. AfCS-Nature Molecule Pages
(2005). (doi:10.1038/mp.a002075.01)

Awards

Miller Fund Award for Innovative Immunology Research
Monte V. Hobbs Student Award
American Heart Association Predoctoral Fellowship