Mentor: Colin Duckett, PhD
The lab studies a protein family known as the Inhibitors of Apoptosis (IAP) and their role in cellular signaling. My work specifically focuses on the roles of cellular IAP1 and 2 (cIAP1 and cIAP2). Contrary to what their name implies, these proteins are involved in a multitude of signaling pathways aside from apoptosis. I am studying how the cIAPs are involved in CD30 signaling. CD30 is a member of the TNF receptor superfamily and is often expressed on certain lymphoma cells. CD30 can activate multiple signaling pathways, many of which are involved in the pathogenesis of various cancers, and it appears that the cIAPs are important for regulating these pathways.
Kocab, A.J., Veloso, A., Paulsen, M.T., Ljungman, M., and Duckett, C.S. (2015) Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling. Oncogene. In Press.
Kenneth, N.S., Hucks, G.E. Jr., Kocab, A.J., McCollom, A.L., Duckett, C.S. (2014) Copper is a potent inhibitor of both the canonical and non-canonical NF-κB pathways. Cell Cycle 13, 1006-1014.
Evelyn, C.R., Bell, J.L., Ryu, J.G., Wade, S.M., Kocab, A., Harzdorf, N.L., Showalter, H.D., Neubig, R.R., Larsen, S.D. (2010) Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg Med Chem Lett 20, 665-672.
Rackham Merit Fellowship