Mentor: Benjamin Segal, MD
In adoptive transfer models of Experimental Autoimmune Encephalomyelitis (EAE), transfer of WT T-cells specific for the myelin epitope, Myelin Oligodendrocyte Glycoprotein (MOG), into WT mice causes inflammation primarily in the spinal chord. This results in an ascending paralysis in the mice. Adoptive transfers of MOG-specific T-cells from IFNg KO mice into WT mice or WT MOG-specific T-cells into IFNg receptor KO mice results in balance issues beginning with a tilt of the head or leaning to one side often progressing to a 'spinning,' phenotype where the mice continuously spin in one direction on the axis of the head to tail. Since myelinated tracts in distinct regions of the CNS serve distinct functions, we hypothesize that the loss of IFNg changes the localization of inflammation and demyelination to tracts critical for maintaining appropriate balance. My project centers around finding specific mechanisms that explain how IFNg influences the localization of inflammation in adoptive transfer models EAE.
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