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Bethany Moore, PhD
The success of hematopoietic stem cell transplant (HSCT) therapy is severely limited by pulmonary complications, including Pseudomonas aeruginosa and Streptococcus pneumoniae. We demonstrated that mice which have fully reconstituted their hematopoietic compartment including alveolar macrophages (AMs) post-bone marrow transplantation (BMT) have impaired host defense against the Gram negative pathogen P. aeruginosa. Impaired innate immunity is related, in part, to increased production of prostaglandin E2 (PGE2) by AMs. Cyclooxygenase (COX)-2 is the rate-limiting enzyme for synthesis of PGE2 from arachidonic acid, and COX-2 expression is elevated in AMs post-BMT. Furthermore, we have also observed changes in scavenger receptor profiles which may be affecting macrophage function post-transplant. Alterations in miRNA expression also observed after transplant may explain the changes in scavenger receptor expression. Therefore, we hypothesized that epigenetic mechanisms and miRNA alterations may be responsible for the defect in BMT AMs.
Zaslona, Z, Okunishi, K, Bourdonnay, E, Domingo-Gonzalez, R, Moore, BB, Lukacs, NW, Aronoff, DM, Peters-Golden, M. 2014. Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. J Allergy Clin Immunol. 133(2):379-387.
Domingo-Gonzalez R and Moore BB. 2013. Defective pulmonary innate immune responses post-stem cell transplantation; review and results from one model system. Front. Immunol. 4:126.
Domingo-Gonzalez, R, Katz, S, Serezani, CH, Moore, TA, LeVine, AM, Moore, BB. 2013. PGE2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of P. aeruginosa and S. aureus post-bone marrow transplant. J Immunol. 190(11):5809-17.
Domingo-Gonzalez, R, Huang, SK, Laouar, Y, Wilke, CA and Moore, BB. 2012.COX-2 Expression is Upregulated by DNA Hypomethylation after Hematopoietic Stem Cell Transplantation. J. Immunol. 189(9):4528-36
Domingo-Gonzalez, R, Smith, AJ, Smith, C, Kaplan, MJ, Moore, BB. Prostaglandin synthesis compromises neutrophil extracellular trap formation post-bone marrow transplant. Gordon Research Conference: Biology of Acute Respiratory Infection. Lucca (Barga), Italy. Feb. 2014. Oral and Poster.
Domingo-Gonzalez, R, Katz, S, Serezani, CH, Moore, TA, LeVine, AM, Moore, BB. 2013. PGE2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of P. aeruginosa and S. aureus post-bone marrow transplant. American Association of Immunologists Conference. Honolulu, HI. May 2013.
Racquel Domingo-Gonzalez, Steven Huang, Yasmina Laouar, Bethany B. Moore. Hypomethylation of the Cox-2 promoter upregulate COX-2 and PGE2 levels post-bone marrow transplant. American Association of Immunologists Conference. Boston, MA, May 4-8 2012.
Racquel Domingo-Gonzalez, Steven Huang, Bethany Moore. Methylation patterns of Cox-2 promoter affect Cox-2 and PGE2 levels post-bone marrow transplant. Autumn Immunology Conference, Chicago, IL, November 20-23 2011.
Cal Storm Underrepresented Minority Fellowship, Gordon Research Conference on Biology of Acute Respiratory Infection, 2014
Rackham Conference International Travel Grant, University of Michigan, 2014
Midwest Affiliate Pre-doctoral Fellowship, American Heart Association, 2013 - 14
Jean Forrest Award, University of Michigan, 2013
Harold and Vivian Shapiro/John Malik/Jean Forrest Award, 2013
The Miller Fund Award for Innovative Immunology Research, 2013
The Monte V. Hobbs Student Award, 2013
Rackham Conference Travel Grant, University of Michigan, 2013
R&D Systems Travel Grant, 2013
FASEB MARC Program Travel Award, American Association of Immunologists Conference, Honolulu, HI, 2013
Rackham Graduate Student Research Grant, University of Michigan, 2012
John Wallace Diversity Award, 2011
Rackham Conference Travel Grant, University of Michigan, 2011