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David Giles
e-mail address: dagiles@umich.edu

Mentor: Benjamin Segal, MD


Research Description

Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system that is characterized by demyelinating lesions containing inflammatory T cells and macrophages.  In experimental autoimmune encephalomyelitis (EAE), an animal model of MS, CD4+ T cells are necessary for disease and transfer of myelin-specific T cells is sufficient to induce paralysis.  Of the differentiated T cell subsets, Th1 and Th17 cells are both capable of transferring disease.  The physical manifestations of disease are similar; however, our lab has previously shown that Th1 and Th17 cells induce distinct cytokine profiles, cellular infiltrates, and histological characteristics.  One such distinction is the predominance of monocytes and macrophages in the central nervous system in Th1-induced disease compared to relatively more neutrophils in Th17-induced disease.  In addition, preliminary data suggests that Th1 and Th17 cells promote distinct macrophage phenotypes.  While the presence of infiltrating monocytes in EAE has been well characterized, little is known about the properties of these cells.  My project investigates the role of T cells in directing monocyte activation and gene expression in the central nervous system and the role of monocytes in the neuropathology of EAE.



Wilson, T.J., Pandey, A.S., Jr, W.R.S., Davis, M.C., Giles, D.A., Chaudhary, N., Gemmete, J.J., and Thompson, B.G. (2014b). Dual antiplatelet therapy plus postoperative heparin and dextran is safe and effective for reducing risk of embolic stroke during aneurysm coiling. Acta Neurochir. (Wien) 156, 855–859.

Wilson, T.J., Davis, M.C., Stetler, W.R., Giles, D.A., Chaudhary, N., Gemmete, J.J., Thompson, B.G., and Pandey, A.S. (2014a). Endovascular treatment for aneurysmal subarachnoid hemorrhage in the ninth decade of life and beyond. J. NeuroInterventional Surg. 6, 175–177.



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