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David Giles
e-mail address: dagiles@umich.edu

Mentor: Benjamin Segal, MD


Research Description

Multiple sclerosis  (MS) is an autoimmune disorder of the central nervous system that is characterized by demyelinating lesions containing inflammatory
T cells, B cells, and macrophages.  Immunohistological examination of MS lesions reveals axonal injury with disruption of cellular transport, swelling of the axonal membrane, and transection.  Axon pathology correlates with the degree of inflammation and with exacerbation of clinical symptoms in the primary and secondary progressive forms of MS.  It remains unclear, however, what mediates this axonal damage and whether oligodendrocyte dysfunction and demyelination is a necessary precursor.  My project examines the role of the inflammatory infiltrates in axonopathy and neuronal injury.



Wilson, T.J., Davis, M.C., Stetler, W.R., Giles, D.A., Chaudhary, N., Gemmete, J.J., Thompson, B.G., Pandey, A.S.  Endovascular treatment for aneurysmal subarachnoid hemorrhage in the ninth decade of life and beyond. 
J Neurointerventional Surg. (2013). doi:10.1136/neurintsurg-2013-010714




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