Mentor: Pan Zheng, MD, PhD
My project involves investigation of a non-antigen-based immune prevention for individuals who have a high risk of developing cancer by rescuing tumor-specific T cells from clonal deletion. It has been previously shown that a blockade of B7.1/2 or lymphotoxin resulted in enhanced cancer resistance in TRAMP mice, a spontaneous prostate cancer model. We want to elucidate the immunological mechanisms that confer this resistance. We also plan to examine whether a blockade of lymphotoxin will confer cancer resistance to intestinal tumors in mice with the APC gene, a model for human colon cancer.
Wong C1, Chen C2, Wu Q3, Liu Y4, Zheng P5. A Critical Role for the Regulated Wnt-Myc Pathway in Naive T Cell Survival. J Immunol. 2014 Nov 26. pii: 1401238. [Epub ahead of print]
Rackham Merit Fellowship