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Glioblastoma Multiforme is one of the worst brain tumors one can have. This tumor rapidly grows and infiltrates the brain leading to severe neurological issues and eventual death. There is no cure for this type of tumor and all treatments that have been used since the discovery of these tumors 75 years ago have yielded in only 15 months of extended survival. The goal of the lab are to find novel therapies and to explore the nature of these tumors. The research foci are expansive and varied in trying to understand the molecular, cellular, and mathematical aspects of tumor invasion and evasion. The heterogeneous nature of tumors have lead to the speculation of cancer stem cells that can direct and modulate tumor growth. We aim to investigate a proper test for the "stemness" of cancer cells and whether or not this property will affect tumor growth or immune evasion.
Baker G, Chockley P, Yadav V.N, Doherty R, Ritt M, Sivaramakrishnan S, Castro M.G, Lowenstein P.R. Natural killer cells eradicate Galectin-1 deficient glioma in the absence of adaptive immunity. Cancer Res. 2014 Jul 18
Lowenstein P.R, Yadav V.N, Chockley P, Castro M.G. There must be a way out of here: Identifying a safe and efficient combination of promoter, transgene, and vector backbone for gene therapy of neurological disease. Molecular Therapy. 2014
Wittmann C*, Chockley P*, Singh S, Pase L, Lieschke GJ, Grabher C. Hydrogen peroxide in inflammation – messenger, guide, assassin. Advances in Hematology. 2012. (co-first author)
Sun Y , Varambally S, Maher C, Cao Q, Chockley P, Toubai T, Malter C, Nieves E, Tawara I, Wang Y, Chinnaiyan A, Reddy P. Targeting of microRNA-142-3p in dendritic cells regulates endotoxin induced mortality. Blood. 2011
Toubai T, Sun Y, Tawara I, Friedman A, Liu C, Evers R, Nieves E, Malter C, Chockley P, Maillard I, Winandy S, Reddy P. Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease. Blood. 2011
Tawara I, Koyama M, Liu C, Toubai T, Thomas D, Evers R, Chockley P, Nieves E, Sun Y, Lowler KP, Malter C, Nishimoto N, Hill GR, Reddy P. Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clinical Cancer Research. 2011