Adam Booth
e-mail address: boothaj@umich.edu

Mentor: Keith Bishop, PhD

Research Description

Solid organ transplantation is the treatment of choice for multiple types of late stage organ failure. While advances in immunosuppressive drugs and donor matching have reduced the frequency of acute graft rejection, chronic rejection remains a significant barrier for long term graft acceptance. Chronic rejection is characterized by progressive interstitial fibrous tissue deposition and vascular occlusion. Currently there is no effective treatment for chronic transplant rejection. Previous studies have implicated that connective tissue growth factor (CTGF) plays a role in promoting chronic transplant rejection. My studies aim to elucidate the role that CTGF plays in chronic heart transplant rejection using a mouse model of this disease.

Publications

Awards

American Heart Association Predoctoral Fellowship