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Zachary Benet
e-mail address: benetzl@umich.edu

Mentor: Irina Grigorova, PhD


Research Description

Effective humoral responses require that antigen specific B and T cells find each other in a lymph node or spleen populated by millions of non-specific cells. Within this interaction, B cells get the appropriate signals from the T cells that enables to them to proliferate and form germinal centers. My research focuses on how activated B cells recruit antigen-specific T cells to the border of the B cell follicle. We are using two-photon microscopy to visualize these interactions in either whole lymph nodes or intravitally in live mice. Computational software is being developed to analyze the images on a cell per cell basis.


Woodhams KL, Benet ZL, Blonsky SE, Hackett KT, Dillard JP. 2012. Prevalence and Detailed Mapping of the Gonococcal Genetic Island in Neisseria meningitidis. Journal of Bacteriology, 194(9):2275.


Abstracts and poster presentations

Benet ZL and Fraser IDC. “Elucidating the cross-talk between Toll-like receptors in macrophages.” National Institutes of Health Intramural Research Fair.
Poster Presentation. National Institutes of Health, Bethesda, MD. June, 2011.

Benet ZL and Grigorova I. “The role of CCL3/4 in the regulation of humoral immunity.” Graduate Program in Immunology Retreat. Poster Presentation. Ann Arbor, Michigan. May, 2013.

Sjoelund S, Nuccio A,
Benet ZL, Mann J, Koppenol-Raab M, Bochnowski A, Manes N, Dutta B, Fraser I, Nita-Lazar A. “A Systems Approach to the Characterization of Toll-like Receptor Response to Different Ligand Stimulation in Macrophages.” 62nd ASMS Conference on Mass Spectrometry and Allied Topics. Baltimore, MD. June, 2014.

Narayanan M, Martins A,
Benet ZL, Tsang J. “Charting the landscape of functional and ‘ambient’ splicing in immune-cell activations.” 22nd Annual International Conference on Intelligent Systems for Molecular Biology. Boston, MA. July, 2014.

Research Presentations

Benet ZL. “Exploring the role of CCL3/4 as Treg guiding cues during humoral immune responses” Immunology Research In Progress Seminar Series, 10/2013

Benet ZL. “Examining the regulatory role of pro-inflammatory cytokines during the humoral immune response.” Immunology Program Seminar Series, 2/2014.


Pre-doctoral fellowship – American Heart Association, 2014-2016

Rackham Graduate Student Research Grant, 2014

Rackham Graduate Student Research Grant, 2013

NIH Intramural Research Training Award, 2009-2011

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