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Beth Lubeck
e-mail address: balubeck@umich.edu

Mentor: Philip King, PhD

Research Description

My research focuses on the role of Ras GTP-ase activating protein (GAP)
p120 RasGAP in immune function and development. Specifically, I am
interested in determining the importance of the GAP domain of p120 RasGAP
in these processes. Currently I am working on determining which aspects of
the p120 RasGAP knockout phenotype are dependent on GAP activity by
generating mice with a point mutation in the p120 RasGAP GAP domain.


Lubeck BA, Lapinski PE, Bauler TJ, Oliver JA, Hughes ED, Saunders TL, King PD. 2014. Blood Vascular Abnormalities in Rasa1(R780Q) Knockin Mice: Implications for the Pathogenesis of Capillary Malformation-Arteriovenous Malformation. Am J Pathol. 2014 Dec;184(12):3163-9. doi: 10.1016/j.ajpath.2014.08.018. Epub 2014 Oct 3.

King PD, Lubeck BA, Lapinski PE. 2013. Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis. Sci Signal 6(264):re1

Oliver JA*, Lapinski PE*, Lubeck BA*, Turner JS, Parada LF, Zhu Y, King PD. 2013. The Ras GTPase-activating Protein Neurofibromin 1 Promotes the Positive Selection of Thymocytes. Mol Immunol 55:292-302. (* = equal contribution)

Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, Sevick-Muraca E, King PD. 2012. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clinical Invest 122(2):733-47


Lubeck BA,  Lapinski PE, Bauler TJ, Oliver JA, Hughes ED, Saunders TL, King PD. RASA1 as a regulator of Ras in cardiovascular development and lymphatic maintenance. Gordon Research Conferences Molecular Mechanisms in Lymphatic Function and Disease, Barga, Italy. March 2014.

Lubeck BA
, Lapinski PE, Bauler TJ, Saunders TL, King PD. Role of p120 RasGAP (RASA1) GAP activity in cardiovascular development in mice. FASEB Regulation and Function of Small GTPases conference, Steamboat Springs, CO, USA. June 2013.


Lymphatic Education & Research Network Young Investigator Conference Scholarship Award, 2014

The Miller Fund Award for Innovative Immunology Research, 2013


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