Shanna Ashley
e-mail address: ashleyxy@umich.edu

Mentor: Beth Moore, PhD

Research Description

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disorder of the lower respiratory tract. This disorder typically affects adults over the age of 50. Much of the research in understanding the disease pathogenesis of IPF has been done in animal models. The cause of the disease is unknown but likely infectious agents can help pre-dispose the lung to fibrotic insults and may also exacerbate the disease. My project studies how viral influenza and bacterial infections alters pathogenesis of pulmonary fibrosis.

Publications

Lackey DE, Ashley SL, Davis AL and Hoag KA. (2008). Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9. J. Nutr. 138:1512-1519.

Raman S, Hsu TH, Ashley SL, and Spindler KR. (2009). Usage of integrin and heparan sulfate as receptors for mouse adenovirus type 1. J. Virol. 83:2831-2838.

Ashley SL, Welton AR, Harwood KM, Van Rooijen N and Spindler KR. (2009). Mouse adenovirus infection of macrophages. Virol. 390:307-314.

Gralinski LE, Ashley SL, Dixon SD and Spindler KR. (2009). Mouse adenovirus type 1-induced breakdown of the blood-brain barrier. J Virol. 83:9398-9401.

Ashley SL, Ameres SM, Gerrard SR, Foreman O, Eaton KA, Weinberg JW,
Spindler KR. (2011). Host genetic variation in susceptibility to Punta Toro Virus.
Virus Res. 157: 71-5.

Nguyen Y, Procario M, Ashley SL, O’Neal WK, Pickles RJ and Weinberg JB. (2011). Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection. Virus Res. 160:351-9.