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Shanna Ashley
e-mail address: ashleyxy@umich.edu

Mentor: Beth Moore, PhD

Research Description

My research is working to understand how the matricellular protein, periostin, activates lung mesenchymal cells to promote fibrotic outcomes.  There is a particular focus on agents which stimulate periostin release, the integrins which recognize periostin in lung mesenchymal cells and the signals which lead to cell survival and activation.


Lackey DE, Ashley SL, Davis AL and Hoag KA. (2008). Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9. J. Nutr. 138:1512-1519.

Raman S, Hsu TH, Ashley SL, and Spindler KR. (2009). Usage of integrin and heparan sulfate as receptors for mouse adenovirus type 1. J. Virol. 83:2831-2838.

Ashley SL, Welton AR, Harwood KM, Van Rooijen N and Spindler KR. (2009). Mouse adenovirus infection of macrophages. Virol. 390:307-314.

Gralinski LE, Ashley SL, Dixon SD and Spindler KR. (2009). Mouse adenovirus type 1-induced breakdown of the blood-brain barrier. J Virol. 83:9398-9401.

Ashley SL, Ameres SM, Gerrard SR, Foreman O, Eaton KA, Weinberg JW,
Spindler KR. (2011). Host genetic variation in susceptibility to Punta Toro Virus.
Virus Res. 157: 71-5.

Nguyen Y, Procario M, Ashley SL, O’Neal WK, Pickles RJ and Weinberg JB. (2011). Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection. Virus Res. 160:351-9.

Ashley, S.L., Jegal Y., Moore, T.A., and Moore, B.B. (2014). γHerpesvirus, but not Pseudomonas aeruginosa or Influenza A (H1N1) Exacerbate Established Murine Lung Fibrosis. Am J Physiol Lung Cell Mol Physiol(Epub ahead of print)


Shanna Ashley and Bethany Moore. Periostin Regulation of Extracellular Matrix Production and Apoptosis in Lung Mesenchymal Cells in Lung Fibrosis.
American Thoracic Society, Poster, May 2014 in San Diego, California

Shanna Ashley
and Bethany B. Moore. Periostin Regulation of Mesenchymal Cells in Lung Fibrosis. Pulmonary Fibrosis Foundation Meeting. Poster Presentation. December 2013 in La Jolla, California.

Shanna Ashley
and Bethany B. Moore. Surfactant Protein A Regulation of Host Defense post-Bone Marrow Transplantation. American Association of Immunologists Meeting. Poster Presentation. May 2013 in Honolulu, Hawaii.


John Wallace Diversity Award (Autumn Immunology Conference), 2014
UNCF Merck Dissertation Research Fellowship, 2014
Monte V. Hobbs Student Award, 2014

FASEB/MARC Travel Grant Award, 2013
Pulmonary Fibrosis Foundation Poster and Travel Grant, 2013

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