Ivan Maillard, MD, PhD
Notch signaling is essential during early stages of T cell development and can control peripheral T cell immunity with context-dependent effects. We use strict genetic loss-of-function approaches to study the role of Notch signaling in different T cell-mediated disorders. Specifically, we have identified Notch as a new critical regulator of donor-derived alloreactive T cells mediating graft-versus-host-disease after allogeneic bone marrow transplantation and myelin-reactive T cells during experimental autoimmune encephalomyelitis. My project involves determining the signaling networks that are defective in Notch-deficient mature T cells in different T cell-mediated disorders and linking these biochemical defects back to direct Notch transcriptional targets.
Yi Zhang, AR Sandy, et al., 2011. Notch signaling is a critical regulator of allogeneic CD4+ T cell responses mediating graft-versus-host disease. Blood 117: 299-308.
Dorsam GP, Hoselton SA, Sandy AR, Samarasinghe AE, Vomhof-DeKrey EE, Dorsam ST and Schuh JM, 2010. Expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma. Microbiol. Immunol. 54: 558-563.
Vomhof-DeKrey, E. E., Hermann, R. J., Palmer, M. F., Benton, K., Sandy, A. R., Dorsam, S., Dorsam, G. P., 2008. TCR signaling and environment affect vasoactive intestinal peptide receptor-1 expression in primary mouse CD4 T cells. Brain, Behav., Immun. 22(7):1032-40.
Ivy T. Tran, Ashley R. Sandy, Alexis Carulli, Gloria T. Shan, Vedran Radojcic, Ann Friedman, Amy Shelton, Linda Samuelson, Minhong Yan, Christian W. Siebel, Ivan Maillard. In vivo blockade of individual Notch ligands and receptors provides a new targeted therapeutic approach in graft-versus- host disease. American Society of Hematology Annual Meeting and Exposition, San Diego, CA, December 2011.
Ashley R. Sandy, Jooho Chung, Ivy Tran, Gloria T. Shan, Ann Friedman, Philip King, Yi Zhang, Ivan Maillard. Notch signaling critically regulates CD4+ and CD8+ T cell responses after allogeneic bone marrow transplantation. The Notch Meeting, Athens, Greece, October 2011.
Ashley R. Sandy, Ivy Tran, Gloria T. Shan, Ann Friedman, Jina Wang, Koji Kato, Shan He, Elizabeth Hexner, Stephen G. Emerson, Warren S. Pear, Yi Zhang and Ivan Maillard. Notch Signaling is a Critical Regulator of Allogeneic T cell Responses Mediated Graft-versus-Host Disease. Oral and poster presentation. Autumn Immunology Conference, Chicago, IL, November 2010.
The Miller Fund Award for Innovative Immunology Research, May 2011