Jeffrey Curtis, MD
Inhaled glucocorticoids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD), although their plieotropic anti-inflammatory function is not fully understood.
I am studying the mechanism by which glucocorticoids increase the uptake of apoptotic cells by alveolar macrophages - generally an anti-inflammatory stimulus - and how these changes may alter macrophage immune function in response to bacterial infection. I am particularly interested in how the combination of inhaled glucocorticoids and apoptotic cells within the lung (such as can be found in the lungs of many COPD and severe asthma patients) changes bacterial phagocytosis and immunopathology after Streoptococcal pneumoniae infection.
McCubbrey AL, Sonstein J, Ames TM, Freeman CM, Curtis JL. 2012. Glucocorticoids Relieve Collectin-Driven Suppression of Apoptotic Cell Uptake in Murine Alveolar Macrophages through Downregulation of SIRPα. J Immunol. Jul 1;189(1):112-9.
Alexandra L McCubbrey & Jeffrey L Curtis: “Corticosteroids Increase Murine Alveolar Macrophage Efferocytosis with Innate Immune Consequences”. Gordon Research Conference - Apoptotic Cell Recognition and Clearance, Lewiston, Maine, July 2011.
Rackham Conference Travel Grant, July 2011
Monte V. Hobbs Student Award, May 2011