Sihyug Jang, Ph.D.
e-mail address: sihyug@umich.edu

Mentor: Nicholas Lukacs, Ph.D.

Techniques Used:
PCR, animal cell culture, Flow cytometer

Research Description:

To determine the role of Notch on immune response and the development of pulmonary pathology in allergic airway disease

Publications:

1. Jang S, Uzelac A, Salgame P.(2008) "Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection" .J Leukoc Biol. 84(5):1264-70.

2. Pompei, L*., Jang, S*., Zamlynny, B., Ravikumar, S., McBride, A., Hickman, SP., and Salgame, P. (2007) “Disparity in Interleukin-12 gene induction in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to utilization of distinct Toll-like receptors” J. Immunology: 178(8):5192-9, * both contributed equally to this work.

3. Gandotra, S., Jang, S., Murray, P., Salgame, P., and Ehrt S. (2007) “NOD2-deficient mice control infection with Mycobacterium tuberculosis” Infection and Immunity: 75(11):5127-34

4. Hanlon, AM, Jang, S., and Salgame P. (2005) “Cbl-b differentially regulates activation induced apoptosis in Th1 and Th2 cells” Immunology. 116(4):507-12.

5. Jang, S., Uematsu, S., Akira S., and Salgame P. (2004), “IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition.” J.Immunology: 173(5):3392-7.

6. Jang, S., Krammer, PH. and Salgame P. (2003), “Lack of proapoptotic activity of soluble CD95 ligand is due to its failure to induce CD95 oligomers,” J Interferon Cytokine Res 23(8): 441-7.

7. Hanlon, AM, Jang, S., and Salgame P. (2002), “Signaling from cytokine receptors that affect Th1 responses.” Front Biosci 7: d1247-54.

Honors and Awards:

2005 - Award for Keystone symposia scholarship, Keystone Symposia, Whistler,
British Columbia, Canada