Matthew Schaller, Ph.D.
e-mail address: mschalle@umich.edu

Mentor: Steven Kunkel, Ph.D.

Techniques Used:
Animal modeling, Cell sorting, Cell transfer


Research Description:

I am broadly interested in the impact of developmental genes on the outcome of inflammatory processes.  To this end I have started two projects that involve some aspect of development and it's relationship to immunology.  One of these projects involves studying the impact of Notch signaling on T cells both in vitro  and in vivo. Our lab has developed specific polyclonal antibodies to both delta4 and jagged1 to aid us in these studies.  In addition I am also interested in the impact of inflammation on adult stem cells.  We are currently studying both hematopoietic and mesenchymal stem cell responses to inflammation.  The results of these studies could provide us with clues as to the long term effects that inflammation can have on the host.

Publications:

Sciaudone M, Yao L, Schaller M, Zinn SA, Freake HC, Diethylenetriaminepentaacetic acid enhances thyroid hormone action by a transcriptional mechanism. Biol Trace Elem Res. 2004 Summer;99(1-3): 219-31.

Gumucio DL, Diaz A, Schaner P, Richards N, Babcock C, Schaller M, Cesena T. Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis. Clin Exp Rheumatol. 2002 Jul-Aug;20(4 Suppl 26):S45-53.

John AE, Gerard CJ, Miller AL, Berlin AA, Schaller MA, Humbles AA, Lukacs NW Respiratory syncytial virus induced exaggeration of allergic disease is dependent upon CCR1-associated immune responses. Eur. J. Immunol. 2004 Dec 10;35(1):108-116

Schaller MA, Lundy SK , Huffnagle GB, and Lukacs NW CD8 + T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivity. Eur. J. Immunol. 2005 Jul; 35(7): 2061-70

Rudd BD, Smit JJ, Flavell RA, Alexopoulou L, Schaller MA, Gruber A, Berlin AA, Lukacs NW Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory virus infection. J Immunol. 2006 Feb 1; 176(3) 1937-1942

Miller AL, Gerard C, Schaller M, Gruber AD, Humbles AA, Lukacs NW Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection. J Immunol. 2006 Feb 15; 176(4) 2562-2567

Schaller, MA Hogaboam, C, Lukacs NW and Kunkel, SL Respiratory viral infections drive chemokine expression and exacerbate asthmatic responses . J Allergy and Clin Immunology 2006 Aug; 118(2) 295-302

Schaller, MA Dissertation: CD8 + T cell Responses in Allergic Airway Disease Defended Novemeber 18 th 2005.

Rudd, BD, Schaller, MA, Smit, JJ, Kunkel, SL, Neupane, R, Kelly, L, Berlin AA, Lukacs NW MyD88 mediate instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection J Immunol 2007 May 1:178(9):5820-7

Lukacs, NW, Smit, JJ, Lindell D, Schaller, M Respiratory syncytial virus induced pulmonary disease and exacerbation of allergic asthma Contrib Microbiol 2007; 14:68-82

Ito, T, Schaller, M, Hogaboam, CM, Standiford, TJ, Chensue, SW, Kunkel, SL TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response Eur J Immunol. 2007 Oct:37(10):2847-55

Coelho, AL, Schaller, MA, Benjamim, CF, Orlofsky, AZ, Hogaboam CM, Kunkel, SL The chemokine CCL6 promotes innate immunity via immune cell activation and recruitment J Immunol 2007 Oct 15:179(8):5474-82

Schaller, MA, Neupane, R, Rudd, BD, Kunkel, SL, Kallal, LE, Lincoln, P, Lowe, JB, Man, Y, Lukacs, NW Notch ligand delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines J Ex. Med. 2007 Nov 26: 204(12) 2925-34

Wen, H, Schaller, MA, Dou, Y, Hogaboam, CM, Kunkel, SL. Dendritic cells at the interface of innate and acquired immunity: the role for epigenetic changes J Leukoc Biol. 2008 Mar; 83(3) 439-36

Schaller, MA Kunkel SL, Lukacs NW A key role for CCR1 in T cell mediated respiratory inflammation. Am. J. Path. 2008 Feb:172(2) 386-94.

Lindell, D Berlin, AA, Schaller, MA , and Lukacs, NW B cell antigen presentation promotes Th2 responses and immunopathology during chronic allergic lung disease. PLoS One 2008 Sep: 3(9): e3129 doi:10.1371/journal.pone.0003129

Honors and Awards:

2004-2005 Miller Fund Award for Innovative Immunology Research,University of Michigan, Ann Arbor, MI