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Jamison Grailer, Ph.D.
e-mail address: jgrailer@umich.edu

Mentor: Peter Ward, M.D.


Techniques Used


Cell culture, ELISA, mouse models, in vitro assays, flow cytometry, immunofluorescence, confocal microscopy, RT-PCR, Western blot


Research Description

Catecholamines (i.e. norepinephrine, epinephrine) can regulate inflammation both positively and negatively. Previous studies in our lab have shown that catecholamines promote inflammation in animal models of acute lung injury. We are interested in how phagocyte-derived catecholamines can regulate lung inflammation, and the mechanism by which this regulation is achieved.


Publications

Subramanian, H, M Kodera, JJ Grailer, RM Conway, DA Steeber.  Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine.  J. Immunol.  (2011) (Submitted manuscript).

Yang, X, H Hong, JJ Grailer, IJ Rowland, A Javadi, SA Hurley, W Cai, DA Steeber, S Gong.  cRGD-functionalized, DOX-conjugated and 64Cu-radiolabeled superparamagnetic iron oxid nanoparticles for targeted anticancer drug delivery and PET/MRI imaging.  Biomaterials. (2011) 32:4151-4160.

Yang, X, JJ Grailer, IJ Rowland, A Javadi, SA Hurley, V. Matson, DA Steeber, and S Gong.  Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anti-cancer drug delivery and ultrasensitive MR imaging.  ACS Nano.  (2010) 4:6805-6817.

Yang, X, JJ Grailer, IJ Rowland, A Javadi, SA Hurley, DA Steeber, and S Gong.  Stable multifunctional SPIO/DOX-loaded wormlike polymer vesicles for targeted cancer therapy and ultrasensitive MR imaging.  Biomaterials.  (2010) 34:9065-9073.

Yang, X, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Tumor-targeting, pH-responsive and stable unimolecular micelles as drug nanocarriers for targeted cancer therapy.  Bioconjug. Chem.  (2010) 21:496-504.

Yang, X, JJ Grailer, S Pilla, DA Steeber, S Gong, and X Shuai.  Multifunctional polymeric vesicles for targeted drug delivery and imaging.  Biofabrication.  (2010) 2: 025004 (8pp).

Grailer, JJ, M Kodera, and DA Steeber.  L-selectin: Role in regulating homeostasis and cutaneous inflammation.  J. Dermatol. Sci.  (2009) 56:141-147.

Grailer, JJ, RM Conway, and DA Steeber.  Lymphocyte subset recruitment during an immune response differs between peripheral and mucosal lymphoid tissues.  J. Immunol.  (2009) 182:95.7.

Prabaharan, M, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Amphiphilic multi-arm-block copolymer based on hyperbranched polyester, poly(L-lactide) and poly(ethylene glycol) as a drug delivery carrier.  Macromol. Biosci.  (2009) 9:515-524.

Prabaharan, M, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(L-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery.  Biomaterals.  (2009) 30:3009-3019.

Prabaharan, M, JJ Grailer, DA Steeber, and S Gong.  Thermosensitive micelles based on folate-conjugated poly(N-vinylcaprolactam)-block-poly(ethylene glycol) copolymers for tumor-targeted drug delivery.  Macromol. Biosci.  (2009) 9:744-753.

Prabaharan, M, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery.  Biomaterials.  (2009) 30:5757-5766.

Zhang, C, H Subramanian, JJ Grailer, A Tiwari, S Pilla, DA Steeber, and S Gong.  Fabrication of biodegradable poly(trimethylene carbonate) networks for potential tissue engineering scaffold applications.  Poly. Adv. Tech.  (2009) 20:742-747.

Prabaharan, M, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphillic block copolymer for tumor-targeted drug delivery.  Biomaterials.  (2009) 30:6065-6075.

Yang, X, S Pilla, JJ Grailer, DA Steeber, S Gong, Y Chen, and G Chen.  Tumor-targeting, superparamagnetic polymeric vesicles as highly efficient MRI contrast probes.  J. Materials Chem.  (2009) 19: 5812-5817.

Tiwari, A, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Biodegradable hydrogels based on novel photopolymerizable guar gum-methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds.  Acta Biomater.  (2009) 5:3441-3452.

Aryal, S, JJ Grailer, S Pilla, DA Steeber, and S Gong.  Doxorubicin conjugated gold nanoparticles as water-Soluble and pH-responsive anticancer drug nanocarriers. J. Materials Chem.  (2009) 19:7879-7884.

Kodera*, M, JJ Grailer*, AP Karalewitz, H Subramanian and DA Steeber.  T lymphocyte migration to peripheral lymph nodes is maintained during homeostatic proliferation.  Microsc. and Microanal.  (2008) 14:211-224.  *Co-first author.

Prabaharan M, JJ Grailer, DA Steeber, and S Gong.  Stimuli-responsive chitosan-graft-poly(N-vinylcaprolactam) as a promising material for controlled hydrophobic drug delivery.  Macromol. Biosci.  (2008) 8:843-851.

Grailer, JJ, M Kodera, AP Karalewitz, H Subramanian, and DA Steeber.  Effects of lymphopenia-induced homeostatic proliferation on T cell recirculation.  Microcirculation.  (2007) 14:465.

Kodera, M, H Subramanian, RM Conway, JJ Grailer, AP Karalewitz, and DA Steeber.   Tracking the immune response using correlative microscopic, flow cytometric, and chemotaxis assays.  Microsc. Microanal.  (2006) 12:30-31.


Honors and Awards

NIH/NHLBI NRSA Lung Immunopathology Training Grant

UWM Graduate School Dissertation Fellowship, 2009-2010

UWM Chancellor’s Fellowship, 2005-2010

UWM Department of Biological Sciences James D. Anthony Award for animal research, 2007-2009

 


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