Pan Zheng , M.D., Ph.D.
Associate Professor
Department of Surgery and Pathology
panz@umich.edu

Research Interests:
Tumor immunology, Cancer Biology, Wnt signal transduction.

Current Research Activity:

Our laboratory is interested in tumor immunology and cancer biology. We study the mechanism in immune tolerance to tumor antigens in cancer models. We explores different ways to rescue the high avidity tumor antigen reactive T cells from negative selection and to modulate the function of regulatory T cells. We also study protein phosphatase as tumor suppressor in Wnt signaling.

Representative Publications:

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y. 2007. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129: 1275-1286.

Ding C, Liu Y, Wang Y, Park BK, Wang CY, Zheng P, Liu Y. 2007. Siglecg Limits the Size of B1a B Cell Lineage by Down-Regulating NFkappaB Activation. PLoS ONE. 2:e997. 3.

Tao Zuo, Runhua Liu, Huiming Zhang, Xing Chang, Yan Liu, Lizhong Wang, Pan Zheng, and Yang Liu. 2007, FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J. Clin. Invest. 117(12): 3765–3773.

Yang Liu and Pan Zheng, 2007. FOXP3 and breast cancer: implications for therapy and diagnosis. Pharmacogenomics. 8(11):1485-1487.

Chen GY, Chen C, Wang L, Chang X, Zheng P, Liu Y. 2008. Cutting
edge: Broad expression of the FoxP3 locus in epithelial cells: a caution
against early interpretation of fatal inflammatory diseases following in
vivo depletion of FoxP3-expressing cells. J Immunol. 180(8):5163-6.

McNally BA, Trgovcich J, Maul GG, Liu , Zheng P. 2008. A role
for cytoplasmic PML in cellular resistance to viral infection. PLoS ONE.
3(5):e2277.

Wang Y, Liu Y, Wu C, McNally B, Liu , Zheng P. 2008. Laforin
confers cancer resistance to energy deprivation-induced apoptosis.
Cancer Res. 68(11):4039-44.