Pan Zheng , M.D., Ph.D.
Professor, Departments of Surgery and Pathology
Hematopoietic stem cells, TSC-mTOR signaling, Tumor immunology, Cancer Biology, Aging Biology
Our laboratory is interested in two areas. One is the role of TSC-mTOR signaling in hematopoietic stem cells and in lymphocyte development. We study the effect of cellular injury, inflammation and inflammatory cytokines in promoting the HSC aging process. The second area is tumor immunology and cancer biology in prostate cancer. We study the mechanism in immune tolerance to tumor antigens in cancer models. We explores different ways to rescue the high avidity tumor antigen reactive T cells from negative selection and to modulate the function of regulatory T cells.
Liu Y and Zheng P. 2007. CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases. Trends Immunol. 28(7):315-20.
Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y. 2007. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129: 1275-1286.
Chen GY, Chen C, Wang L, Chang X, Zheng P, Liu Y. 2008. Cutting
edge: Broad expression of the FoxP3 locus in epithelial cells: a caution
against early interpretation of fatal inflammatory diseases following in
vivo depletion of FoxP3-expressing cells. J Immunol. 180(8):5163-6.
Wang Y, Liu Y, Wu C, McNally B, Liu Y, Zheng P. 2008. Laforin confers cancer resistance to energy deprivation-induced apoptosis. Cancer Res. 68(11):4039-44.
Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. 2008. TSC/mTOR maintains quiescence and functions of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205:2397-408.
Liu RH, Wang LZ, Chen C, Liu Y, Zhou PH, Wang Y, Wang XR, Turnbull J, Minassian BA, Liu Y, Zheng P. 2008. Laforin negatively regulates cell cycle progression through GSK-3β dependent mechanisms. Mol. Cell. Biol. 28:7236-44.
Zhou P, Zheng X, Zhang H, Liu Y, Zheng P. 2009. B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer. Clin Cancer Res 15:960-970.
Liu RH, Wang LZ, Chen G, Katoh H, Chen C, Liu Y, Zheng P. 2009. FOXP3 Up-regulates p21 Expression by Site-specific Inhibition of Histone Deacetylase 2/4 Association to the Locus. Cancer Res 69:2252-2259.
Chen GY, Tang J, Zheng P, Liu Y. 2009. CD24 and Siglec-10 Selectively Repress Tissue Damage- Induced Immune Responses. Science 323:1722-1725. PMID: 19264983.
Chen C, Liu Y, Liu Y, Zheng P. 2009. The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells. Cell Cycle 8(8): 1158-69. PMID: 19270502.
Chen C, Liu Y, Liu Y, Zheng P. 2009. mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells. Science Signaling 2:ra75.
Zhou P, Fang XF, McNally BA, Yu P, Zhu MZ, Fu YX, Wang LZ, Liu Y, Zheng P. 2009. Targeting Lymphotoxin-mediated Negative Selection to Prevent Prostate Cancer in Mice with Genetic Predisposition. Proc Natl Acad Sci U S A. 106(40):17134-9.
Wang LZ, Liu RH, Li W, Chen C, Katoh H, Chen GY, McNally BA, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. 2009. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell 16(4):336-46.