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Michal Olszewski, D.V.M., Ph.D.
Research Biologist,
Veteran Affairs Ann Arbor Healthcare System
Assistant Professor of Internal Medicine, Pulmonary Division

olszewsm@umich.edu


The scientific interest of our group focuses on the interface of the adaptive and innate immunity during host-pathogen interactions. The development of protective responses against fungal and bacterial pathogens are a common theme of these studies. The mechanisms involved in the pathogenesis of Cryptococcus neoformans infection and the persistence of this microbe are the main focus of our work. The interplay between host and microbial factors on different aspects of the host response to this pathogenic yeast are extensively studied, including T cell polarization, activation of innate immune cells (macrophages and dendritic cells), cytokine signaling, changes in leukocyte activation patterns, and control of dissemination of this pathogen from lungs into the CNS.


Recent Publications

Chen GH, McNamara DA, Hernandez Y, Huffnagle GB, Toews GB and Olszewski MA. Inheritance of Immune Polarization Patterns is linked to Resistance versus Susceptibility to Cryptococcus neoformans in a Mouse Model. Infection and Immunity; 76: 2379-2391, 2008

Osterholzer JJ, Surana R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL, Huffnagle GB, Toews GB, Olszewski MA: Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung. Am J Pathol; 174: 932-943, 2009

Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski MA: Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99. Am J Pathol; 175: 2489-2500 2009

Qiu Y, Zeltzer S, Zhang Y, Wang F, Chen G, Murdock BJ, Toews GB, Bhan U, Osterholzer JJ, Standiford TJ, Olszewski, MA. Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection. J. Immunol: 2012; 188:3940-8

Qiu Y, Davis MJ, Dayrit J, Hadd ZD, Meister DL, Osterholzer JJ, Williamson PR,
Olszewski, MA. Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in mice. 2012, PLoS ONE 7(10): e47853. doi:10.1371/journal.pone.0047853

He X, Lyons DM, Toffaletti DL, Zhang Y, Wang F, Qiu Y, Lee A, Dayrit J, Perfect JR,
Olszewski, MA. Virulence Factors Identified by Cryptococcus neoformans Mutant Screen Differentially Modulate Lung Immune Responses and Brain Dissemination. Am J Pathol; 2012; 181:1356-66

Qiu Y, Davis MJ, Dayrit JK, Carolan J, Osterholzer JJ, Curtis JL,
Olszewski, MA. Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection. J Immunol. 2013 ;191(1):238-48;

Davis MJ, Tsang T, Dayrit JK, Qiu Y, Freij JB, Huffnagle GB,
Olszewski, MA. Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection. MBio. 2013; 4(3)/mBio.00264-13


 


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