Mary O'Riordan, Ph.D.
Assistant Professor,
Department of Microbiology and Immunology
oriordan@umich.edu

Research Description:

Our laboratory explores the interaction of intracellular bacterial pathogens
with their host cells. We primarily study the Gram-positive bacterium
Listeria monocytogenes, a facultative intracytosolic pathogen, investigating
mechanisms of adaptation to the host cell environment. In addition, we use
L. monocytogenes as a model pathogen with which to explore host mechanisms that regulate infection and innate immune signaling.

Projects in the lab include:

1. Characterizing host transporters that modulate bacterial entry into the
host cytosol

2. Defining bacterial factors that facilitate rapid intracellular
replication of L. monocytogenes

3. Elucidating molecular mechanisms that govern induction of proinflammatory
cytokines in response to cytosolic bacteria

Selected Publications:

Y. Li, L. Delbridge Bauler and M. O¹Riordan. Distinct mechanisms of
restricting Listeria Infection in immature and mature dendritic cells. In
revision.

K. Keeney, L. Colosi, W. Weber and M. O¹Riordan. 2009. Generation of
branched chain fatty acids through lipoate dependent metabolism facilitates
intracellular growth of Listeria monocytogenes. In press - Journal of
Bacteriology.

M. O¹Riordan, L. Bauler, F. Scott and C. Duckett. 2008. Inhibitor of
Apoptosis (IAP) Proteins in eukaryotic evolution and development: a model of
thematic conservation. Developmental Cell. Oct;15(4):497-508.

L. Delbridge Bauler, C. Duckett and M. O¹Riordan. 2008. XIAP regulates
cytosolic-specific innate immunity to Listeria infection. PLoS Pathogens.
Aug 29;4(8):e1000142.

A. Radtke and M. O¹Riordan. 2008. Homeostatic maintenance of
pathogen-containing vacuoles requires TBK1-dependent regulation of
aquaporin-1. Cellular Microbiology. Jul 8 [Epub ahead of print].

K. Keeney, J. Stuckey and M. O¹Riordan. 2007. LplA1-dependent utilization
of host lipoyl-peptides enables Listeria cytosolic growth and virulence.
Molecular Microbiology. Oct 1 [Epub ahead of print].

A. Radtke, L. Delbridge S. Balachandran, G. Barber and M. O¹Riordan. 2007. TBK1 protects vacuolar integrity during intracellular bacterial infection.
PLoS Pathogens. Mar 2;3(3):e29.

L. Delbridge and M. O¹Riordan. Innate recognition of intracellular bacteria.
Current Opinion in Immunology. 2006 Nov 23; [Epub ahead of print].

A. Radtke and M. O¹Riordan. Innate resistance to intracellular bacterial
pathogens. 2006. Cellular Microbiology. Nov;8(11):1720-9.

V. Auerbuch, D. Brockstedt, N. Meyer-Morse, M. O¹Riordan and D. Portnoy. 2004. Mice lacking the Type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med. 200(4):527-33.

R. McAffrey, P. Fawcett, M. O¹Riordan, K.D. Lee, E. Havell, P. Brown and D. Portnoy. 2004. A cytosol-specific program of gene expression induced by
Gram-positive intracytosolic bacteria. Proc. Natl. Acad. Sci. 101(31):11386-91.

M. O¹Riordan, M. A. Moors and D. A. Portnoy. 2003. Listeria intracellular
growth and virulence require host-derived lipoic acid. Science. 302(5644):
462-4.

M. O¹Riordan and D. A. Portnoy. 2002. The host cytosol: front-line or home
front? Trends in Microbiology 10(8): 361-364.

M. O¹Riordan, C. H. Yi, R. Gonzales, K. D. Lee and D. A. Portnoy. 2002.
Innate recognition of bacteria by a macrophage cytosolic surveillance
pathway. Proc. Natl. Acad. Sci. 99(21): 13861-13866.