Text Image: UM Medical School: Graduate Program in Immunology
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Michele Swanson, Ph.D.
Professor of Microbiology and Immunology
Director, Office of Postdoctoral Studies


We exploit the intracellular bacterial pathogen Legionella pneumophila to investigate how macrophages recognize and fight infection.  
Currently, we focus on the recruitment and contribution of autophagy to immunity. 

Representative Publications

Autophagy, Infection and the Immune Response, W. Jackson and M. Swanson, editors.  Wiley-Blackwell Press, in press.

Byrne, B. G., J.-F. Dubuisson, A. D. Joshi, J. J. Persson and M. S. Swanson:Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection.  mBio 4(1): doi:10.1128/mBio.00620-12, 2013.

Joshi, A. D. and M. S. Swanson:  Secrets of a successful pathogen:  Legionella resistance to progression along the autophagic pathway. Front. Microbio. 2:138, 2011.

Morris, S., M. S. Swanson, A. Lieberman, M. Reed, Z. Yue, D. M. Lindell, and N. W. Lukacs:  Autophagy-mediated DC activation is essential for innate cytokine production and APC function with Respiratory Syncytial Virus responses.  J. Immunol. 187:3953, 2011. 

Flynn, K. J. and M. S. Swanson.  Integrative Conjugative Element ICE-βox confers oxidative stress resistance to Legionella pneumophila in vitro and in macrophages.  mBio 5 (3), e01091-14, 2014.

Molofsky, A. B., B. G. Byrne, N. N. Whitfield, C. A. Madigan, E. T. Fuse, K. Tateda, and M. S. Swanson:  Cytosolic recognition of flagellin by murine macrophages restricts Legionella pneumophila infection.  J. Exp. Med. 203:1093-104, 2006.

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