Richard A. Miller, M.D., Ph.D.
Professor, Department of Pathology
Associate Director, Geriatrics
www-personal.umich.edu/~millerr/RAM_home_page.htm

millerr@umich.edu

My laboratory works on the biology of aging and longevity in mice, with special emphasis on how aging alters T cell activation. Projects underway focus on a number of related research areas: (a) the role of protein kinases and cytoskeletal
elements in T lymphocyte activation; (b) restoration of full immune function to aged T cells using enzymes that cleave surface glycoproteins, and (c) testing methods for improving immune responses to tumors and protein antigens. In addition to our work in immunology, the laboratory studies the biochemistry of
cellular stress resistance and its relationship to life span in long-lived mutant mice. For more information, see the lab web site above.

Recent Publications

Berger, S. B, A. A. Sadighi Akha, and R. A. Miller. 2005. A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice. International Immunology 17:983-991.

Miller, R. A., S. B. Berger, D. T. Burke, A. Galecki, G. G. Garcia, J. M. Harper, and A. A. Sadighi-Akha. 2005. T cells in aging mice: genetic, developmental and biochemical analyses. Immunological Reviews 205: 94 – 103.

Berger, S. B., A. A. Sadighi Akha, R. A. Miller, and G. G. Garcia. 2006. CD43-independent augmentation of mouse T cell function by glycoprotein cleaving enzymes. Immunology 119: 178 - 186.

Sadighi Akha, A. A., S. B. Berger, R. A. Miller. 2006. Enhancement of CD8 T cell function through modifying surface glycoproteins in young and old mice. Immunology 119: 187 - 194.

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