Ilona Kryczek, Ph.D.
Research Assistant Professor,
Department of Surgery
Interaction between immune cells and cancer cells
The etiology and progress of cancer is strongly associated with inflammatory environment. People with a chronic inflammatory process have an increased risk of developing several cancers suggesting the strong immune inflammatory conditioning. Although, extrinsic mechanisms provided by the tumor microenvironment are essential for forming the stem cell niche, the involvement of host immune system in this process is not understood. We believe that immune cells can actively and directly regulate the genetic and epigenetic mechanisms involved in tumor dissemination, relapse and metastasis.
Representative Recent Publications
Kryczek I, Zhao E, Liu Y, Wang Y, Vatan L, Szeliga W, Moyer J, Klimczak A, Lange A, Zou W. Human TH17 Cells Are Long-Lived Effector Memory Cells. Science Translational Medicine, 2011, 3(104):104ra100.
Kryczek I, Wu K, Zhao E, Wei S, Vatan L, Szeliga W, Huang E, Greenson J, Chang A, Rolinski J, Radwan P, Fang J, Wang G, Zou W. IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer. Journal of Immunology, 2011 1;186(7):4388-95.
Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W. Phenotype, distribution, generation, functional and clinical relevance of Th17 cells in the human tumor environments; Blood. 2009; 114(6):1141-9.
Kryczek I, Wei S, Szeliga W, Vatan L, Zou W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood. 2009; 114(2):357-9.
Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J, Chang A, Zou W. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. Journal of Immunology, 2007, 178(11):6730-3.
Kryczek I, Wei S, Vatan L, Escara-Wilke J, Szeliga W, Keller ET, Zou W. Cutting Edge: Opposite Effects of IL-1 and IL-2 on the Regulation of IL-17+ T Cell Pool IL-1 Subverts IL-2-Mediated Suppression. Journal of Immunology, 2007, 179(3):1423-6.