Margaret R. Gyetko, M.D.
Professor of Internal Medicine
Division of Pulmonary and Critical Care
Senior Associate Dean for Faculty Affairs and
Faculty Development
mgyetko@umich.edu

Dr. Margaret Gyetko's research addresses lung inflammation and immune responses, with emphasis on the role of urokinase-type plasminogen activator (uPA and the urokinase receptor (uPAR). Areas of investigation include the interaction of the uPA/uPAR system with cytokine networks, and the subsequent effects on immune and inflammatory responses; and the requirement for uPA/uPAR for leukocyte/lymphocyte activation and recruitment. Ongoing work in the laboratory investigates the uPA/uPAR system on the molecular and biochemical levels using both in vitro and in vivo models, including transgenic murine models.

Representative Publications

Gyetko MR, Chen GH, McDonald RA, Goodman R, Huffnagle G, Wilkinson CC, Fuller JA, Toews GB. Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans: A murine transgenic model. J. Clin. Invest 97:1818-1826, 1996.

Sitrin RG, Todd III RF, Petty HR, Brock TG, Shollenberger SB, Albrecht E, Gyetko MR. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J. Clin. Invest 97:1942-1951, 1996.

Beck JM, Preston AM, Gyetko MR. Urokinase-type plasminogen activator in inflammatory cell recruitment and host defense against Pneumocystis carinii in mice. Infection and immunity 67:879-884, 1999

Gyetko MR, Sud S, Kendall T, Standiford TJ. Urokinase Receptor-Deficient Transgenic Mice have Impaired Neutrophil Recruitment in Response to Pulmonary Pseudomonas Infection. Journal of Immunology 165: 1513-1519, 2000.

Gharaee-Kermani M, Hu B, Phan SH, Gyetko MR. The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy.  Expert opinion on investigational drugs 2008: 17(6): 905-916.

Shetty S. Bhandary YP. Shetty SK. Velusamy T. Shetty P. Bdeir K. Gyetko MR. Cines DB. Idell S. Neuenschwander PF. Ruppert C. Guenther A. Abraham E. Shetty RS.  Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.  Am J Respir Crit Care Med. 2010: 181(12):1355-66.