Text Image: UM Medical School: Graduate Program in Immunology
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Grace Chen, M.D., Ph.D.
Assistant Professor of Internal Medicine,
Division of Hematology/Oncology
gchenry@umich.edu



Research Description

My laboratory is interested in understanding how the host immune system and the gut microbiota modulate intestinal inflammation and carcinogenesis using mouse models.  Specifically, we have focused on understanding the mechanism by which certain members of the Nod-like receptor (NLR) family that are largely involved in the sensing of bacteria protect against the development of inflammation-induced colon tumorigenesis.  We are also investigating how the gut microbiota regulates colon tumorigenesis using germfree and gnotobiotic mice as well as attempting to identify tumor-suppressive and tumor-promoting bacterial populations through bacterial sequencing and analysis of stool from wildtype and NLR-deficient mice during the development of chemically-induced inflammation and tumors. 

 

Representative Publications

Chen GY, Shaw MH, Redondo G, Núñez G. The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res. 2008 Dec 15; 68(24):10060-7.  PMID 19074871, PMC2804847

*Chen GY, Liu M, Wang F, Bertin J, Núñez G.  A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol. 2011 Jun 15; 186(12):7187-94. Epub 2011 May 4.  PMID 21543645, PMC3133458. *Corresponding author

*Chen GY, Núñez G.  Inflammasomes in intestinal inflammation and cancer. Gastroenterology. 2011 Dec; 141(6):1986-99. Epub 2011 Oct 15. Review.  PMID 22005480, PMC3442608.  *Co-corresponding author

Zhan, Y., Chen, PJ, Sadler, WD, Wang, F, Poe, S, Nunez, G, Eaton, KA, and Chen, GY. Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Res. 2013 Oct 28. [Epub ahead of print] PMID: 24165160

Zackular, JP, Baxter, NT, Iverson, KD, Sadler, WD, Petrosino, JF, Chen, GY, and Schloss, PD. The gut microbiome modulates colon tumorigenesis.  Mbio 2013 4(5), article available online 11/5/13.  *Co-corresponding author

 


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