The goal of our laboratory is to investigate the immune pathogenesis of autoimmune disorders including thyroid associated orbitopathy (TAO) and rheumatoid arthritis with the ultimate goal of translating our research findings into clinical applications. We have well established collaborations with other investigators examining the molecular basis of allied autoimmune disorders. This collaborative approach has garnered new insights and has provided several novel areas for investigation.
Douglas RS, Naik V, Hwang CJ, Afifiyan NF, Gianoukakis AG, Sand D, Kamat S, Smith TJ B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: Implications for disease pathogenesis. J Immunol 181:5768-74, 2008
Hwang CJ, Afifiyan N, Sand D, Naik V, Said J, Pollock SJ, Chen B, Phipps RP, Goldberg RA, Smith TJ, Douglas RS Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. Invest Ophthalmol Vis Sci 50:2262-8, 2009
Douglas RS, Tsirbas A, Gordon M, Lee D, Khadavi N, Garneau HC, Goldberg RA, Cahill K, Dolman PJ, Elner V, Feldon S, Lucarelli M, Uddin J, Kazim M, Smith TJ, Khanna D Development of criteria for evaluating clinical response in thyroid eye disease using a modified Delphi technique. Arch Ophthamol 127:1155-60, 2009
Douglas RS, Afifiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 95:430-8, 2010
Gillespie EF, Raychaudhuri N, Papageorgiou KI, Atkins SJ, Lu Y, Charara LK, Mester T, Smith TJ, Douglas RS. Interleukin-6 (IL-6) production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: Involvement of Akt and NF-kappaB. Invest Ophthalmol Vis Sci. 2012; 53(12):7746-53.