Text Image: UM Medical School: Graduate Program in Immunology
Text Image: Faculty

Raymond Douglas, M.D., Ph.D.
Director, Thyroid Eye Disease Center
Associate Professor of Ophthalmology
Ophthalmic and Orbital Surgery
raydougl@umich.edu


Research Focus

The goal of our laboratory is to investigate the immune pathogenesis of autoimmune disorders including thyroid associated orbitopathy (TAO) and rheumatoid arthritis with the ultimate goal of translating our research findings into clinical applications. We have well established collaborations with other investigators examining the molecular basis of allied autoimmune disorders.  This collaborative approach has garnered new insights and has provided several novel areas for investigation. 


Current Research Activity

Our laboratory team is currently studying the role of infiltrating and circulating fibroblast precursors in this process with the ultimate goal of translating our research findings into clinical applications. Our laboratory has acquired the expertise and unique skill sets in three areas requisite for completing these long term goals. First, we have personnel including myself with scientific training in immunology. I completed my dissertation at the University of Pennsylvania under the direction of Peter Nowell MD, investigating the aberrant cytokine response of lymphocytic tumors. This training established the groundwork for future investigations of the immunologic mechanisms of human disease. Second, my clinical training as an ophthalmologist, orbital surgeon and current clinical practice is restricted to patients with autoimmune orbital disorders and thus has provided the opportunities to translate novel therapeutic approaches. Third, we have established robust collaborations with other investigators examining the molecular basis of allied autoimmune disorders. 


Representative Publications

Douglas RS, Naik V, Hwang CJ, Afifiyan NF, Gianoukakis AG, Sand D, Kamat S, Smith TJ B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: Implications for disease pathogenesis. J Immunol 181:5768-74, 2008

Hwang CJ, Afifiyan N, Sand D, Naik V, Said J, Pollock SJ, Chen B, Phipps RP, Goldberg RA, Smith TJ, Douglas RS  Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1.  Invest Ophthalmol Vis Sci 50:2262-8, 2009

Douglas RS, Tsirbas A, Gordon M, Lee D, Khadavi N, Garneau HC, Goldberg RA, Cahill K, Dolman PJ, Elner V, Feldon S, Lucarelli M, Uddin J, Kazim M, Smith TJ, Khanna D  Development of criteria for evaluating clinical response in thyroid eye disease using a modified Delphi technique.  Arch Ophthamol 127:1155-60, 2009

Douglas RS, Afifiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ  Increased generation of fibrocytes in thyroid-associated ophthalmopathy.  J Clin Endocrinol Metab 95:430-8, 2010

Gillespie EF, Raychaudhuri N, Papageorgiou KI, Atkins SJ, Lu Y, Charara LK, Mester T, Smith TJ, Douglas RS. Interleukin-6 (IL-6) production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: Involvement of Akt and NF-kappaB. Invest Ophthalmol Vis Sci. 2012; 53(12):7746-53.

 

 



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