Pan Zheng , M.D., Ph.D.
Associate Professor
Department of Surgery and Pathology
panz@umich.edu

Research Interests:
Tumor immunology, Cancer Biology, Wnt signal transduction.

Current Research Activity:

Our laboratory is interested in tumor immunology and cancer biology. We study the mechanism in immune tolerance to tumor antigens in cancer models. We explores different ways to rescue the high avidity tumor antigen reactive T cells from negative selection and to modulate the function of regulatory T cells. We also study protein phosphatase as tumor suppressor in Wnt signaling.

Representative Publications:

Liu Y and Zheng P. 2007. CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases. Trends Immunol. 28(7):315-20.

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y. 2007. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129: 1275-1286.

Chen GY, Chen C, Wang L, Chang X, Zheng P, Liu Y. 2008. Cutting
edge: Broad expression of the FoxP3 locus in epithelial cells: a caution
against early interpretation of fatal inflammatory diseases following in
vivo depletion of FoxP3-expressing cells. J Immunol. 180(8):5163-6.

Wang Y, Liu Y, Wu C, McNally B, Liu Y, Zheng P. 2008. Laforin confers cancer resistance to energy deprivation-induced apoptosis. Cancer Res. 68(11):4039-44.

Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. 2008. TSC/mTOR maintains quiescence and functions of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205:2397-408.

Liu RH, Wang LZ, Chen C, Liu Y, Zhou PH, Wang Y, Wang XR, Turnbull J, Minassian BA, Liu Y, Zheng P. 2008. Laforin negatively regulates cell cycle progression through GSK-3β dependent mechanisms. Mol. Cell. Biol. 28:7236-44.

Zhou P, Zheng X, Zhang H, Liu Y, Zheng P. 2009. B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer. Clin Cancer Res 15:960-970.

Liu RH, Wang LZ, Chen G, Katoh H, Chen C, Liu Y, Zheng P. 2009. FOXP3 Up-regulates p21 Expression by Site-specific Inhibition of Histone Deacetylase 2/4 Association to the Locus. Cancer Res 69:2252-2259.

Chen GY, Tang J, Zheng P, Liu Y. 2009. CD24 and Siglec-10 Selectively Repress Tissue Damage- Induced Immune Responses. Science 323:1722-1725. PMID: 19264983.

Chen C, Liu Y, Liu Y, Zheng P. 2009. The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells. Cell Cycle 8(8): 1158-69. PMID: 19270502.