Text Image: UM Medical School: Graduate Program in Immunology
Text Image: Faculty

Massimo Pietropaolo, M.D.
Director, Laboratory of Immunogenetics
Brehm Scholar
Brehm Center for Type 1 Diabetes Research and Analysis
Professor of Internal Medicine, Pediatrics


Research Interests

Humoral Immune responses in Autoimmune Diabetes; Identification of novel molecular targets of Autoimmune Diabetes;  Intrinsic properties of Marginal Zone B cells in Autoimmune Diabetes


Recent Publications

Pietropaolo M , Surhigh JM, Nelson PW, Eisenbarth GS. Primer: Immunity and Autoimmunity. Diabetes (in press)

Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol 87 ( 4 ): 197-209, 2008.

Pietropaolo M , Barinas-Mitchell E, Kuller LH. Heterogeneity of Diabetes Mellitus. Unraveling a Dispute: Is Systemic Inflammation Related To Islet Autoimmunity? Diabetes . 56: 1189-1197, 2007.

Barinas-Mitchell E, Kuller LH, Pietropaolo S, Zhang YJ, Henderson T, Pietropaolo M . The Prevalence of GAD65 Autoantibodies by Glucose Tolerance Status in Elderly Patients from the Cardiovascular Health Study. J Clin Endocrinol Metab 91(8):2871-2877, 2006.

Barinas-Mitchell E, Pietropaolo S, Zhang YJ, Henderson T, Trucco M Kuller LH, Pietropaolo M . Islet cell autoimmunity in a Trethnic Adult Population of the national Health and Nutrition Examination Survey (NHANES) III, Diabetes 53(5):1293-1302, 2004.

Friday RP, Pietropaolo SL, Profozich J, Trucco M, Pietropaolo M. Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus . J Biol Chem 278(2):853-63, 2003.

Spitzenberger, F., Pietropaolo, S., Verkade, P., Habermann, B., Lacas-Gervais, S., Mziaut, H., Pietropaolo, M ., and Solimena, M. ICA69 is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem 278:26166-73, 2003.

Pietropaolo M , Giannoukakis, Trucco M. Cellular environment and freedom of gene expression. Nature Immunol 3;4:335 2002.

Pietropaolo M , Becker DJ, LaPorte RE, Dorman JS, Riboni S, Rudert WA, Mazumdar S. Trucco M. P rogression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes. Diabetologia 45:66-76, 2002 .

Pietropaolo M , Barinas-Mitchel E, Pietropaolo SL, Kuller LH, Trucco M. Evidence of islet cell autoimmunity in patients with Type 2 diabetes mellitus. Diabetes 49:32-38, 2000.

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