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Sihyug Jang, Ph.D.
e-mail address: sihyug@umich.edu

Mentor: Nicholas Lukacs, Ph.D.

Techniques Used:
PCR, animal cell culture, Flow cytometer

Research Description:

To determine the role of Notch on immune response and the development of pulmonary pathology in allergic airway disease



1. Jang S, Uzelac A, Salgame P.(2008) "Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection" .J Leukoc Biol. 84(5):1264-70.

2. Pompei, L*., Jang, S*., Zamlynny, B., Ravikumar, S., McBride, A., Hickman, SP., and Salgame, P. (2007) “Disparity in Interleukin-12 gene induction in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to utilization of distinct Toll-like receptors” J. Immunology: 178(8):5192-9, * both contributed equally to this work.

3. Gandotra, S., Jang, S., Murray, P., Salgame, P., and Ehrt S. (2007) “NOD2-deficient mice control infection with Mycobacterium tuberculosis” Infection and Immunity: 75(11):5127-34

4. Hanlon, AM, Jang, S., and Salgame P. (2005) “Cbl-b differentially regulates activation induced apoptosis in Th1 and Th2 cells” Immunology. 116(4):507-12.

5. Jang, S., Uematsu, S., Akira S., and Salgame P. (2004), “IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition.” J.Immunology: 173(5):3392-7.

6. Jang, S., Krammer, PH. and Salgame P. (2003), “Lack of proapoptotic activity of soluble CD95 ligand is due to its failure to induce CD95 oligomers,” J Interferon Cytokine Res 23(8): 441-7.

7. Hanlon, AM, Jang, S., and Salgame P. (2002), “Signaling from cytokine receptors that affect Th1 responses.” Front Biosci 7: d1247-54.


Honors and Awards:

2005 - Award for Keystone symposia scholarship, Keystone Symposia, Whistler,
British Columbia, Canada


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