Cirrhosis


Cirrhosis Functional Ability

Enrollment Status: OPEN

Objective

Patients with cirrhosis may experience a decline in their thinking ability and memory, physical ability and endurance, muscle strength, balance, and other functions. We want to try to identify the limitations that lead to functional disabilities in older cirrhosis patients.

Design

Patients will undergo surveys, blood draw, CT scan, food diary, physical/cognitive testing. Patients will also wear an armband to collect data about physical activity.

Inclusion criteria

Age 50 and older with a clinical diagnosis of cirrhosis.

Referrals or questions

See contact information below


Fitbit Ancillary Study

Enrollment Status: OPEN

Objective

Patients with cirrhosis may experience a decline in their thinking ability and memory, physical ability and endurance, muscle strength, balance, and other functions. We want to try to identify the limitations that lead to functional disabilities in older cirrhosis patients.

Design

Patients will wear a pedometer (Fitbit) for 1 month and upload step-count information via the internet.

Inclusion criteria

Age 50 and older with a clinical diagnosis of cirrhosis.

Referrals or questions

See contact information below


Pathophysiology of Sarcopenia in Cirrhosis

Enrollment Status: OPEN

Objective

  • Determine the histological changes in skeletal muscles of patients with cirrhosis and sarcopenia.
  • Demonstrate dys-regulation of intracellular signaling in the muscle of patients with cirrhotic sarcopenia.
  • Determine whether ex vivo contractile function is abnormal in muscle fibers from patients with cirrhotic sarcopenia.

Design

Patients will undergo some or all of the following: surveys, blood draw, CT scan, food diary, leg strength exercise, muscle biopsy. Three groups are being enrolled:

  • Patients with cirrhosis
  • Healthy patients
  • Patients with cirrhosis undergoing abdominal surgery

Contact persons for referrals or questions