Nonalcoholic Fatty Liver Disease (NAFLD) / Nonalcoholic Steatohepatitis (NASH)


A 5-year longitudinal observational study of patients with nonalcoholic fatty liver disease or nonalcoholic steatohepatitis (TARGET-NASH)

Sponsor: TARGET PharmaSolutions

Enrollment status: Actively enrolling

Objective

The goal of this research study is to observe any treatment for NAFLD/NASH in a large number of people in a "real-life" setting. Researchers are interested in observing how lifestyle changes, counseling, or other treatments work in patients who are treated by their doctors in routine practice.

Inclusion criteria

Exclusion criteria

Study design

Principal investigator: Anna Lok, MD, aslok@med.umich.edu

Contact person: Christine Patton, (734) 647-0236 or pattochr@med.umich.edu


University of Michigan–Peking University Joint Initiative

Role of visceral adiposity in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in lean versus obese patients: A comparative study between patients at University of Michigan Health System versus Peking University Health Science Center

Enrollment status: Actively enrolling

Objective

To use a novel technique, analytic morphomics, to quantify visceral adipose tissue, ectopic adipose tissue and quality of fat in lean persons with NAFLD versus lean persons with no NAFLD and obese persons with NAFLD to understand why some lean persons develop fatty liver and to understand the role of fat in the abdomen on development of fatty liver.

Inclusion criteria

Exclusion criteria

Study design

Principal investigator: Anna Lok, MD, aslok@med.umich.edu

Contact persons:
Sravanthi Kaza, (734) 615-3853 or sravanth@med.umich.edu
Elizabeth Wu, elizwu@med.umich.edu


Uptake, efficacy, and sustainability of a structured mobile technology-based lifestyle program for patients with non-alcoholic fatty liver disease (NAFLD)

Enrollment status: Actively enrolling

Objective

The primary aim of this study is to assess the feasibility and acceptability of a mobile technology-based structured lifestyle program for patients with non-alcoholic fatty liver disease (NAFLD). The secondary aim is to examine the changes in metabolic and liver-related clinical parameters, health-related quality of life (HRQOL), physical activity, and nutritional characteristics among patients with NAFLD enrolled in the structured lifestyle program.

Study design

This is a prospective observational study of adult patients with a clinical diagnosis of NAFLD followed in the Michigan Medicine Hepatology clinics. Participants will complete several surveys, measurements, and lab tests during the initial visit and repeat these tests after 6 months. Throughout their enrollment in the study, participants will wear a Fitbit Zip pedometer during waking hours every day and receive weekly emails with their step counts.

Inclusion criteria

Exclusion criteria

Principal investigator: Monica Konerman, MD, MSc, konerman@med.umich.edu

Contact person: Jane Wong, (734) 232-0284 or janejw@med.umich.edu


Patient knowledge, attitudes, and behaviors related to non-alcoholic fatty liver disease

Enrollment status: Actively enrolling

Objective

The aim of this study is to assess patient knowledge, attitudes, and behavior related to non-alcoholic fatty liver disease (NAFLD) at baseline and after receiving a comprehensive education packet regarding the diagnosis and management of NAFLD. We will also assess health-related quality of life (HRQOL).

Study design

This is a survey-based study of NAFLD patients evaluated and managed in the Michigan Medicine Hepatology Clinic. The baseline survey will be administered during a routine clinic visit or during an elective research visit through the clinical research center. Patients will be given a patient education folder after completion of the initial survey. A repeat survey will be completed at 6 months.

Inclusion criteria

Exclusion criteria

Principal investigator: Monica Konerman, MD, MSc, konerman@med.umich.edu

Contact person: Jane Wong, (734) 232-0284 or janejw@med.umich.edu