Acute Liver Failure

Acute liver failure and acute liver injury observational study

Enrollment status: OPEN

A multi-center NIH study initiated in 1997 is looking at acute liver failure and severe acute liver injury in adults. The aim of this study is to gather prospective demographic and clinical data on patients with acute liver failure and acute liver injury with varying etiologies.

Inclusion criteria

• INR ≥ 1.5 with or without encephalopathy due to any cause

Informed consent may be obtained from a family member.

Blood and urine samples, clinical data, and survival will be obtained × 7 days.

Contacts for referrals or questions:

Principal investigator: Robert Fontana, MD, rfontana@med.umich.edu

• Christine Poulsen, MLA, (734) 936-4886 or chpoulse@med.umich.edu

• Navya Chiramana, MPharm, (734) 936-4886 or cnavya@med.umich.edu

ALF-MBT: ¹³C-methacetin breath test (MBT) for the prediction of outcome in acute liver failure (ALF)

Enrollment status: OPEN

To assess the safety and utility of the ¹³C-methacetin breath test system in predicting survival in adult patients with acute liver failure.

Inclusion criteria

• Adult men or women (18–70 years of age)
• Severe acute liver injury
• INR ≥ 1.5
• Presence of any degree of hepatic encephalopathy
• Duration of illness <26 weeks
• Enrolled in the Acute Liver Failure Study Group (ALFSG) registry

Informed consent may be obtained from a family member.

Test will be performed on Day 1, 2, 3, 5, and 7 of study enrollment.

Contacts for referrals or questions:

Principal investigator: Robert Fontana, MD, rfontana@med.umich.edu

• Christine Poulsen, MLA, (734) 936-4886 or chpoulse@med.umich.edu

• Navya Chiramana, MPharm, (734) 936-4886 or cnavya@med.umich.edu

ROTEM: Potential use of rotational thromboelastometry to explore hemostatic abnormalities in patients with acute liver failure or acute liver injury

Enrollment status: OPEN

The goal of this study is prove that ROTEM is a reliable tool to help doctors identify subjects with acute liver failure or acute liver injury who will or will not have a greater tendency to bleed.

Inclusion criteria

• Enrolled in the Acute Liver Failure Study Group (ALFSG) registry
• Presence of any degree of hepatic encephalopathy
• INR ≥ 1.5 with or without encephalopathy due to any cause

Informed consent may be obtained from a family member.

Blood will be obtained × 5 days.

Contacts for referrals or questions:

Principal investigator: Robert Fontana, MD, rfontana@med.umich.edu

• Christine Poulsen, MLA, (734) 936-4886 or chpoulse@med.umich.edu

• Navya Chiramana, MPharm, (734) 936-4886 or cnavya@med.umich.edu