A multi-center NIH study initiated in 1997 is looking at acute liver failure and severe acute liver injury in adults. The aim of this study is to gather prospective demographic and clinical data on patients with acute liver failure and acute liver injury with varying etiologies.
Informed consent may be obtained from a family member.
Blood and urine samples, clinical data, and survival will be obtained × 7 days.
Principal investigator: Robert Fontana, MD, rfontana@med.umich.edu
Christine Poulsen, MLA, (734) 936-4886 or chpoulse@med.umich.edu
Navya Chiramana, MPharm, (734) 936-4886 or cnavya@med.umich.edu
To assess the safety and utility of the 13C-methacetin breath test system in predicting survival in adult patients with acute liver failure.
Informed consent may be obtained from a family member.
Test will be performed on Day 1, 2, 3, 5, and 7 of study enrollment.
Principal investigator: Robert Fontana, MD, rfontana@med.umich.edu
Christine Poulsen, MLA, (734) 936-4886 or chpoulse@med.umich.edu
Navya Chiramana, MPharm, (734) 936-4886 or cnavya@med.umich.edu
The goal of this study is prove that ROTEM is a reliable tool to help doctors identify subjects with acute liver failure or acute liver injury who will or will not have a greater tendency to bleed.
Informed consent may be obtained from a family member.
Blood will be obtained × 5 days.
Principal investigator: Robert Fontana, MD, rfontana@med.umich.edu
Christine Poulsen, MLA, (734) 936-4886 or chpoulse@med.umich.edu
Navya Chiramana, MPharm, (734) 936-4886 or cnavya@med.umich.edu