Inclusion criteria

Exclusion criteria

• Cirrhosis with ascites

• Serum creatinine ≥ 2.0 mg/dL

• Oliguria lasting at least six hours, defined as < 300 mL/24h urinary output

• Unresponsive to fluid challenge of 1.5 L NS with or without albumin within the previous 48 hours or documented central venous pressure (CVP) > 12

• History of allergy or hypersensitivity to ifetroban

• Pregnant or nursing

• Age < 18 years

• SCr > 5.0 mg/dL

• Platelet count at screening of <30,000

• Active gastrointestinal hemorrhage

• Evidence of obstructive or parenchymal renal disease

• NYHA class 3 or 4 heart failure

• Presence of HCC not transplantable by Milan criteria

• Cardiopulmonary arrest without full recovery of mental status

• Moribund and death expected within five days

• Uncontrolled bacterial or fungal infections, defined as receiving appropriate antimicrobial therapy for > 24 hours

• Burns > 30% body surface area

• Exposed to investigational drugs within 30 days before CTM administration.

• Inability to understand the requirements of the study.

• Refusal to provide written authorization for use and disclosure of protected health information.

• Be otherwise unsuitable for the study, in the opinion of the Investigator