Irritable Bowel Syndrome (IBS)
Testing biological markers in the blood of people with irritable bowel syndrome to develop a test panel that will help diagnose functional gastrointestinal diseases
IRB# HUM00027087
Principal Investigator: Richard J. Saad, MD
Study Coordinator: Lina Nahlawi, e-mail: lnahlawi@med.umich.edu, telephone: 734-936-2761
Study Description
Participants in the study are required to come once or twice to the study office. You will complete questionnaires and you will be asked to donate blood about 5 tablespoons. The test results will not be made available to you. Financial compensation is provided for your time and for travel expenses. If you qualify to enroll in the study but do not have a colonoscopy/sigmoidoscopy procedure done within the past 5 years, the study will offer you this test at no cost to you.
Subject Eligibility
Age Range: 18 to 70 years
Gender: male and female
Ethnicity: all
Race: all
Smoking: smoking and non-smoking volunteers
Medication: no restriction
This study is seeking: both healthy subjects and patients with specified condition.
Other eligibility factors:
- Must have active symptoms of irritable bowel syndrome
- Women must not be pregnant or breast feeding or have given birth within 6 months prior
- Must have had a colonoscopy/sigmoidoscopy and random colonic mucosal biopsies
- Must not be depressed or have other functional disorders such as fibromyalgia, migraine
- Must not be diabetic or have a history of colorectal cancer or inflammatory bowel disease
- Must withhold certain medication prior to the blood draw
- Must not have viral or bacterial infection 2 weeks prior to giving blood for study testing
- Did not have major abdominal surgery excluding cholecsystectomy, appendectomy, hysterectomy
- Not have a first-degree relative diagnosed with celiac or Inflammatory bowel disease
- Must not be HIV positive or have viral hepatitis or autoimmune disease
Compensation: $75 to $125
Expected Recruitment End Date: December 2009
