Irritable Bowel Syndrome (IBS)
Comparing two forms of dietary therapy to control the symptoms of irritable bowel syndrome with diarrhea (IBS-D): a randomized, controlled trial and gastrointestinal microbiome analysis
The study compares two diets that have been recommended for improving symptoms associated with IBS.
The study is seeking adults with irritable bowel syndrome with diarrhea (IBS-D) whose abdominal discomfort and diarrhea are not well controlled. After a 2-week screening period, during which the severity of symptoms will be assessed and eligibility determined, patients will be randomized to receive one of two diets: Diet 1 or Diet 2, to which they will adhere for 4 weeks. In addition, stool and blood samples will be collected before and after randomization to measure relevant biomarkers.
- This study is seeking 18 years or older male and female patients with diarrhea-predominant IBS condition.
- Must NOT have constipation more than 25% of the time
- Female childbearing potential must not be pregnant
- Must not have inflammatory bowel disease (Crohn's disease, ulcerative colitis, microscopic colitis), pancreatitis, or Hirschsprung's disease, or prior bowel obstruction
- Must not have prior bowel resection (accepted is appendectomy, cholecystectomy, and polyp removal)
- Must not have uncontrolled diabetes or thyroid function, or have hepatitis, B or C, or HIV
- Must not have chronic kidney, heart, or lung disease that may prevent study completion.
- Must not have untreated cancer
- Must not take antibiotic, probiotic, or narcotic pain medication while in the study.
Expected Recruitment End Date: January 2014
Principal Investigator: Shanti Eswaran, MD
Study Coordinator: Lina E-mail: LNahlawi@med.umich.edu, Telephone: (734) 936-2761