Idiosyncratic Liver Injury Associated with Drugs (ILIAD)

The goal of the ILIAD protocol is to create a database and bank of biological specimens (DNA, plasma, lymphocytes) from individuals with severe drug-induced liver injury (DILI) due to isoniazid (INH), phenytoin (Dilantin), amoxicillin/clavulanate (Augmentin), or valproic acid (Depakote) after January 1, 1994. This study is funded by the NIH/NIDDK.

Study Design

• Telephone or personal interview of medical history surrounding DILI event
• Single blood draw
• Participant receives $75

Please contact Suzanne Welch @ (734) 936-4886, toll free 1-866-UM liver, or swelc@umich.edu or Dr. Robert Fontana rfontana@med.umich.edu for referrals or questions.

For more information see the following websites:
Drug-Induced Liver Injury Network http://dilin.dcri.duke.edu/index.html
NIH funds network to study drug-induced liver injury http://www.nih.gov/news/pr/nov2004/niddk-19.htm
Press Release: U-M helps lead national study of liver damage http://www.med.umich.edu/opm/newspage/2004/liverstudy.htm

1-866-UM-LIVER
swelc@umich.edu

A Multicenter, Longitudinal Study of Drug- and CAM-Induced Liver Injury

The goal of this NIH study is to prospectively identify bona fide cases of liver injury due to drugs and complementary and alternative medications (CAM) within 6 months of onset. Clinical data, blood, DNA, and urine will be collected from affected patients and matched controls for mechanistic and genetic studies.

Study Design

• All subjects have a baseline and 6-month follow-up visit at the GCRC that includes: surveys, medical history, blood and urine collection.
• Patients with liver injury at 6 months return for 12- and 24-month visits.

Costs

• Costs of study lab tests provided by sponsor (NIDDK).
• Subjects receive $50 for each completed study visit.

Please contact Suzanne Welch @ (734) 936-4886, toll free 1-866-UM liver, or swelc@umich.edu or Dr. Robert Fontana rfontana@med.umich.edu for referrals or questions.

For more information see the following websites
Drug-Induced Liver Injury Network http://dilin.dcri.duke.edu/index.html
NIH funds network to study drug-induced liver injury http://www.nih.gov/news/pr/nov2004/niddk-19.htm
Press Release: U-M helps lead national study of liver damage http://www.med.umich.edu/opm/newspage/2004/liverstudy.htm

1-866-UM-LIVER
swelc@umich.edu