Drug-Induced Liver Injury
Idiosyncratic liver injury associated with drugs (ILIAD)
Enrollment status: OPEN
The goal of the ILIAD protocol is to create a database and bank of biological specimens (DNA, plasma, lymphocytes) from individuals with severe drug-induced liver injury (DILI) due to isoniazid (INH), phenytoin (Dilantin®), amoxicillin/clavulanate (Augmentin®), minocycline, nitrofurantoin, trimethroprim/sulfamethoxazole (Bactrim®), or valproic acid (Depakote®) after January 1, 1994. This study is funded by the NIH/NIDDK.
- Telephone or personal interview of medical history surrounding DILI event
- Single blood draw
- Participant receives $75
Contacts for referrals or questions: Please see below.
A multicenter, longitudinal study of drug-induced and complementary and alternative medication-induced liver injury
Enrollment Status: OPEN
The goal of this multicenter NIH study is to prospectively identify bona fide cases of liver injury due to drugs and complementary and alternative medications (CAM) within 6 months of onset. Clinical data, blood, DNA, and urine will be collected from affected patients and matched controls for mechanistic and genetic studies.
- All subjects have a baseline and 6-month follow-up visit at the University of Michigan Health System, which includes surveys, medical history, blood and urine collection.
- Patients with liver injury at 6 months return for 12- and 24-month visits.
- Costs of study lab tests provided by sponsor (NIDDK).
- Subjects receive $50 for each completed study visit.
Contacts for referrals or questions for both studies:
Principal Investigator: Robert Fontana, MD – firstname.lastname@example.org
- Sophana Mao, BS – (734) 936-4886 or email@example.com
For more information, see the following web sites:
Drug-Induced Liver Injury Network – http://dilin.dcri.duke.edu/index.html
NIH funds network to study drug-induced liver injury – http://www.nih.gov/news/pr/nov2004/niddk-19.htm
NIDDK LiverTox – http://www.livertox.nih.gov/