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Irritable Bowel Syndrome (IBS)

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Comparing two forms of dietary therapy to control the symptoms of irritable bowel syndrome with diarrhea (IBS-D): a randomized, controlled trial and gastrointestinal microbiome analysis

IRB# HUM00053274

Purpose

The study compares two diets that have been recommended for improving symptoms associated with IBS.

Description

The study is seeking adults with irritable bowel syndrome with diarrhea (IBS-D) whose abdominal discomfort and diarrhea are not well controlled. After a 2-week screening period, during which the severity of symptoms will be assessed and eligibility determined, patients will be randomized to receive one of two diets: Diet 1 or Diet 2, to which they will adhere for 4 weeks. In addition, stool and blood samples will be collected before and after randomization to measure relevant biomarkers.

Subject Eligibility

Compensation: $120

Expected Recruitment End Date: January 2014

Principal Investigator: Shanti Eswaran, MD

Study Coordinator: Lina E-mail: LNahlawi@med.umich.edu, Telephone: (734) 936-2761


A study to compare the use of two different diets to reduce or improve loose stools or bowel incontinence

IRB# HUM00079064

Purpose

This study will compare two diets to see which one is more effective in improving or eliminating accidental bowel leakage (which is also called fecal incontinence). One diet is using foods that are low in fermentable carbohydrates and the other diet is using foods high in fiber.

Description

Study patients will be in the study for six weeks and will be expected to come to the investigator’s office for 4 visits, each visit lasting 1-2 hours.  Subjects will be asked to record symptoms daily during the 6 weeks. This will take approximately 5 minutes per day. Patients will be given dietary counseling for 4 weeks to asses if diet can help control the symptoms they are experiencing.

Responsibilities as a study patient will include the following:

The first two weeks, study patients will record symptoms daily to see if they will qualify for the study. The last 4 weeks, patients will be on the study diet and will record symptoms daily.

At the end of the study, study patients will be offered additional diet counseling for the alternate diet.

Follow-up survey (optional)

Subject Eligibility

This study is looking for patients who are experiencing fecal incontinence, bowel leakage, loose stool or other issues of bowel control.

Compensation: $120

Expected Recruitment End Date: December 2015

Principal Investigator: Stacy Menees, MD

Study Coordinator: Kenya E-mail: Kenya@med.umich.edu, Telephone: (734) 764-9226