Publications from UM Glenn Laboratory Scientists

Miller, R. A. Genes against aging. 2012. J. Gerontol. A Biol. Sci. Med. Sci. 67:495-502. PMID: 22459617

Miller, R. A., D. E. Harrison, C. M. Astle, E. Fernandez, K. Flurkey, M. Han, M. A. Javors, X. Li, N. L. Nadon, J. F. Nelson, S. Pletcher, A. B. Salmon, Z. D. Sharp, S. Van Roekel, L. Winkleman, R. Strong. 2014. Rapamycin-mediated lifespan increase in mice is dose and sex-dependent and metabolically distinct from dietary restriction. Aging Cell 13:468-477. PMID: 24341993

Harrison, D. E., R. Strong, D. B. Allison, B. N. Ames, C. M. Astle, H. Atamna, E. Fernandez, K. Flurkey, M. A. Javors, N. L. Nadon, J. F. Nelson, J. W. Simpkins, D. Smith, J. E. Wilkinson, and R. A. Miller. 2014. Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13:273-282. PMID: 24245565

W.-C. Chiang, D. Tishkoff, B. Yang , J. Wilon-Grady, X. K. Yu, T. Mazer, M. Eckersdorff, S. Gygi, D. B. Lombard*, and A.-L. Hsu*. 2012. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 localization and function during stress. PLoS Genetics. 8(9): e1002948. PMID: 23028355

W.-C. Chiang, T.-T. Ching, H. C. Lee, C. Mousigian, and A.-L. Hsu*. 2012 HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock response and modulation of longevity. Cell. 148(1-2): 322-334. PMID: 22265419

T.-T. Ching, W.-C. Chiang, C.-S. Chen, and A.-L. Hsu*. 2011. Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity. Aging Cell. 10(3): 506-519. PMID: 21348927

T.-T. Ching, A. Paal, A. Mehta, L. Zhong, and A.-L. Hsu*. 2010. drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans.” Aging Cell. 9(4): 545-557. PMID: 20456299

Gendron CM, Kuo TH, Harvanek ZM, Chung BY, Yew JY, Dierick HA, Pletcher SD. Drosophila life span and physiology are modulated by sexual perception and reward. Science. 2014;343(6170):544-8. PubMed PMID: 24292624; PMCID: 4042187

Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SD. Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proc Natl Acad Sci U S A. 2014;111(22):8137-42. PubMed PMID: 24821805; PMCID: 4050545

Ro J, Harvanek ZM, Pletcher SD. FLIC: high-throughput, continuous analysis of feeding behaviors in Drosophila. PLoS ONE. 2014;9(6):e101107. PubMed PMID: 24978054; PMCID: 4076220

Libert S, Zwiener J, Chu X, Vanvoorhies W, Roman G, Pletcher SD. Regulation of Drosophila life span by olfaction and food-derived odors. Science. 2007;315(5815):1133-7. PubMed PMID: 17272684

Giblin W, Skinner ME, and Lombard DB. 2014. Sirtuins: guardians of mammalian healthspan TIG 30:271-86. PMCID: 4077918

Park J, Chen Y, Tishkoff D, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BMM, Skinner ME, *Lombard DB+*, and Zhao Y+. 2013. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell 50:919-30. PMCID: 3769971 +co-senior authorship

Lombard DB, Alt FW, Cheng H, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis MC, Guarente LP, Farese R, Weissman S, Verdin E, and Schwer B. 2007. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. MCB 27:8807-14. PMCID: 2169418

Sebastian C, Zwaans BMM, Silberman M, Zhong L, Toiber D, Martinez B, Cosentino C, Etchegaray J-P, Giacosa S, Goren A, Gimrek A, Truelove J, Greenson J, *Lombard DB+*, and Mostoslavsky R+. 2012. The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell 157:1185-1199. PMCID: 3526953 +co-senior authorship

Gibbons GS, Owens SR, Fearon ER, Nikolovska-Coleska Z. Regulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L. ACS Chem Biol. 2014 Nov 10, DOI:10.1021/cb500668u

Abulwerdi FA, Liao C, Mady A, Gavin J, Shen C, Cierpicki T, Stuckey JA, Showalter HD, Nikolovska-Coleska Z. 3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR and Biological Evaluation J Med Chem. 2014, 57(10):4111-33 PMCID: PMC4033665

Abulwerdi F, Liao C, Liu M, Azmi AS, Aboukameela A, Mady AS, Gulappa T, Cierpicki T, Owens S, Zhang T, Sun D, Stuckey JA, Mohammad RM, Nikolovska-Coleska Z. A novel small-molecule inhibitor of Mcl-1 Blocks pancreatic cancer growth in vitro and in vivo. (Highlighted in Molecular Cancer Therapeutics Press Release, March 2014) Mol Cancer Ther. 13(3): 565-75, 2014. PMCID: PMC4174574

Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH. The Role of HTS in Drug Discovery at the University of Michigan. Comb Chem High Throughput Screen. 2014, 17(3): 210-30. PMCID: PMC4166557

Shen C, Jo SY, Liao C, Hess JL, Nikolovska-Coleska Z. Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins. J Biol Chem. 2013, 288(42):30585-96. PMCID: PMC3798529

Bajwa N., Liao C., Nikolovska-Coleska Z. Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review. Expert Opin Ther Pat 2012, 22(1):37-55. PMCID: PMC3547649

Pal A, Huang W, Li X, Toy KA, Nikolovska-Coleska Z, Kleer CG. CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer. Cancer Res. 2012, 72(18):4818-28. PMCID: PMC3506182

Du Y, Nikolovska-Coleska Z*, Qui M, Li L, Lewis I, Dingledine R, Stuckey JA, Krajewski K, Roller P, Wang S, Fu H. A Dual-Readout F2 Assay That Combines Fluorescence Resonance Energy Transfer and Fluorescence Polarization for Monitoring Bimolecular Interactions. Assay Drug Dev Technol., 2011, 9(4):382-93. PMCID: PMC3148108 (*Co-corresponding author)

Pfisterer PH, Shen C, Nikolovska-Coleska Z, Schyschka L, Schuster D, Rudy A, Wolber G, Vollmar AM, Rollinger JM, Stuppner H. In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. Bioorg Med Chem. 2011, 19(2):1002-9

Issued Patents

Nikolovska-Coleska, Z.; Showalter, H.D.; Mohammad, R.; Liao, C.; Abulwerdi, F.; Small Molecule Inhibitors of Mcl-1 and the uses thereof, WO 2013/052943 A2