Zhang Z, Lu Q-J, Deng C and Richardson B. Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter. Mech Ageing Dev 2002, 123: 1257-1268.
Tra J, Kondo T, Lu Q, Kuick R, Hanash S, and Richardson B. Infrequent Occurrence of Age-Dependent Changes in CpG Island Methylation as Detected by Restriction Landmark Genome Scanning. Mech Ageing Dev 2002, 123:1487-1503.
Yung R, Ray D, Eisenbraun J, Deng C, Attwood J, Eisenbraun M, Johnson K, Miller RA, Hanash S, and Richardson B.. Unexpected effects of a heterozygous Dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity. J Gerontol Biol Sci 2001, 56A: B268-B276.
Lu Q, Wu A, Ray D, Deng C, Attwood J, Hanash S, Pipkin M, Lichtenheld M, and Richardson B. DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol 2003 170: 5118-5123.
Golbus, J, Palella, TD, and Richardson , BC : Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur. J. Immunol. 1990, 20:1869-1872.
Richardson B. Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. J Nutr . 2002, 132:2401S-5S.
Richardson BC . Impact of aging on DNA methylation. Ageing Research Reviews 2003, 2/3:245-261.
Bruce Richardson MD PhD is currently a Professor of Medicine at the University of Michigan and Chief of Rheumatology at the Ann Arbor VA hospital. He received his MD and PhD in Immunology from the University of Chicago , did postdoctoral training at UCSF, and has been on the faculty at the University of Michigan since 1982. His area of interest is the role that DNA methylation plays in regulating T cell gene expression, and how changes in T cell DNA methylation patterns contribute to autoimmunity and immune senescence. He has written more than 75 peer reviewed articles and 30 reviews primarily in the areas of DNA methylation, autoimmunity and aging. This work has been recognized by the Association of Military Surgeons of the United States, which in 2000 presented him the Phillip Hench award for his work demonstrating that procainamide and hydralazine induce autoimmunity by inhibiting T cell DNA methylation. He has also been named Eminent Scientist and Outstanding Scholar of the Year 2001 by the International Research Promotion Council for his studies on DNA modification by the cell, and the role that abnormal methylation plays in disease development. . He is currently on the Board of Directors of the DNA Methylation Society, and co-editor of a Clinical Immunology issue dedicated to DNA Methylation in the Immune System . He has also been an invited speaker at 4 NIH workshops on the pathogenesis of autoimmunity, and on DNA methylation as it relates to disease states.
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