Richard A. Miller, M.D., Ph.D.

Title and department:

Professor of Pathology, Associate Director for Research, Geriatrics Center
Research Professor, Institute of Gerontology, Medical School
University of Michigan
Research Scientist, Veterans Affairs Ann Arbor Healthcare System
Geriatric Research, Education and Clinical Center

Address:

Room 3001 BSRB
University of Michigan,
109 Zina Pitcher Place,
Ann Arbor , MI 48109-2200

Phone:

936 2122 (office);
936 8198 (secretarial);
936 2164 (lab)

E-mail: millerr@umich.edu

Research Interests:

The Miller laboratory studies the genetics, cell biology and immunology of aging, mostly using mouse model systems. Current projects include analyses of genes that modify life span and age-dependent traits, studies of mouse mutants that show delayed aging, dissection of age-related changes in T cell signal transduction, and work on the relationship of cellular stress resistance to life span and disease resistance.

Recent Publications:

Lipman, R., A. Galecki, D. T. Burke and R. A. Miller. 2004. Genetic loci that influence cause of death in a heterogeneous mouse stock. J. Gerontol. Biol. Sci. 59A: 977 – 983.

Berger, S. B, A. A. Sadighi Akha, and R. A. Miller. 2005. A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice. International Immunology 17:983-991

Garcia, G. G., S. B. Berger, A. A. Sadighi Akha, and R. A. Miller. 2005. Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells. Eur. J. Immunol. 35: 622-631.

Miller, R. A., G. Buehner, Y. Chang, J. M. Harper, R. Sigler, and M. Smith-Wheelock. 2005. Methionine-deficient diet extends mouse life span, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4:199-125.

Miller, R. A., S. B. Berger, D. T. Burke, A. Galecki, G. G. Garcia, J. M. Harper, and A. A. Sadighi-Akha. 2005. T cells in aging mice: genetic, developmental and biochemical analyses. Immunological Reviews 205: 94 – 103.

Salmon, A. B., S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller. 2005. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. American Journal of Physiology: Endocrinology and Metabolism 289:E23-E29.

Brief Biography:

Richard A. Miller, M.D., Ph.D., is a Professor of Pathology and Associate Director of the Geriatrics Center at the University of Michigan ; he is also a Research Scientist at the Ann Arbor DVA Medical Center . He received the BA degree in 1971 from Haverford College , and MD and PhD degrees from Yale University in 1976-1977. After postdoctoral studies at Harvard and Sloan-Kettering, he moved to Boston University in 1982 and then to his current position at Michigan in 1990. Dr. Miller has served in a variety of editorial and advisory positions on behalf of the Gerontology Society of America, the American Federation for Aging Research, and the National Institute on Aging. He is the recipient of the Nathan Shock Award, the AlliedSignal Award, and the Kleemeier Award for aging research. His main research interests are in the genetic and immunobiological aspects of aging. His laboratory works on topics ranging from biochemistry of signal transduction in T cells from aged mice, studies of gene expression in long-lived mutant dwarf mice, mapping of genes for longevity and resistance to late-life diseases, to the development of new mouse models for alterations in the rate of aging.

Links to laboratory or personal web pages:

Richard A. Miller Home Page