Evan T. Keller, D.V.M., Ph.D.

Title and department:

Associate Professor, Dept of Pathology
Associate Professor, Dept. of Urology
Medical School
Research Associate Professor,
Institute of Gerontology
University of Michigan

Campus Address: RM 5304 CCGCB, Box 0940

Phone(s): office (734)615-0280 secretary (734)647-8121

Email address: etkeller@umich.edu

Research Interests

Our team is attempting to determine what influences prostate cancer to metastasize and specifically how it interacts with bone. Another research focus of our group is exploring the mechanism through which aging modulates gene expression. We have been primarily focused on oxidative stress as a mediator of gene expression. Finally, we are developing zebrafish as a model for aging.

Recent Publications

Keller ET and J. Brown JM. Osteoprotegerin (OPG), receptor activator of NF k B ligand (RANKL) and RANK in cancer metastasis. Research Advances in Cancer 3:81-93, 2003.

McCauley LK, Tozum TF, Kozloff KM, Koh-Paige AJ, Chen C, Demashkieh M, Cronovixh H, Richard V, Keller ET, Rosol TJ, Goldstein SA. Transgenic models of metabolic bone disease: Impact of estrogen receptor deficiency on skeletal metabolism. Connect Tissue Res 44(Suppl. 1):250-263, 2003.

Murtha JM, Qi W, Keller ET.. Hematologic and serum biochemical values for zebrafish (Danio rerio). Comp Med 53:37-41, 2003.

Murtha JM, Qi W, Keller ET. Characterization of the Heat Shock Response in Mature Zebrafish (Danio rerio). Experimental Gerontol. 38:683-691, 2003.

Fu Z, Smith PC, Zhang L, Rubin M, Dunn RL, Yao Z, Keller ET. Effects of Raf Kinase Inhibitor Protein Expression on Suppression of Prostate Cancer Metastasis. J Natl Cancer Inst.95:878-889, 2003. Has accompanying editorial.

Varani J, Fligiel H, Zhang J, Aslam MN, Lu Y, Dehne LA, Keller ET. Separation of retinoid-induced epidermal thickening from skin irritation. Arch Dermatol Res. 295:255-262, 2003.

Pfitzenmaier J, Quinn JE, Odman AM, Zhang J, Keller ET, Vessella RL, Corey E. Characterization of C4-2 prostate cancer bone metastases and their response to castration. J Bone Min Res. 18:1882-1888, 2003.

Zhang J, Dai J, Yao Z, Lu Y, Dougall W, Keller ET. Soluble RANK-Fc diminishes prostate cancer progression in bone. Cancer Res. 63:7883-7890, 2003.

Brief Biography

Dr. Keller received his Doctor of Veterinary Medicine degree and his Masters in Epidemiology form the University of California-Davis in 1985. He received a Ph.D. in Developmental Biology from the University of Wisconsin-Madison in May, 1996. Dr. Keller completed an Oncology Residency at the University of Wisconsin-Madison from 1990-1992. He also completed postdoctoral training in Molecular Endocrinology from 1992-1995. Dr. Keller was board certified in Veterinary Medical Oncology by the American College of Veterinary Internal Medicine in 1993. He received a John A. Hartford Foundation Student Travel Award at The American Geriatric Society/ American Federation of Aging Research Annual Meeting; the New Investigator Award for Outstanding Achievement in Biological Aging Research at the Institute on Aging, Eighth Annual Colloquium, University of Wisconsin-Madison; the Distinguished Research Award at the Annual Meeting of the American College of Veterinary Internal Medicine, and the Merck US Human Health/American Geriatrics Society New Investigator award at the American Geriatrics Society Annual Meeting. Dr. Keller served as Deputy Editor for the Journal of Gerontology: Medical Sciences from 1999-2000. Dr. Keller is currently an Associate Professor of Urology and Pathology at the University of Michigan . He is Director of the Nathan Shock Center Mutant and Transgenic Rodent Core, and is Co-director of the Connective Tissue Oncology Program of the Comprehensive Cancer Center . Dr. Keller's areas of interest include molecular biology of the androgen receptor, age-related modulation of transcriptional control and prostate cancer skeletal metastasis.