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Raymond Yung, M.B., Ch.B

Title and department:Dr. Raymond Yung
Professor of Internal Medicine
Chief, Division of Geriatric and Palliative Medicine
Co-Director, Geriatrics Center
Director, Institute of Gerontology
University of Michigan

Associate Director, Research
Geriatric Research, Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare System

Mailing address:
University of Michigan Geriatrics Center
300 North Ingalls
Room 909
Ann Arbor, MI 48109-2007

Phone: 734-615-0143; Fax: 734-936-2116

Lab address:
University of Michigan Geriatrics Center
BSRB Room 3023
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Phone: 734-761-7686; Fax: 734-761-7489

E-mail: ryung@umich.edu

Research Interests
Dr. Yung's research focuses on understanding the relationship between immune senescence and the development of immune and inflammatory diseases in the elderly. Aging represents a state of low grade inflammation. Dr. Yung has shown that upregulation of T cell chemokine response occurs in aging animals and humans. The epigenetic `drift' that occurs with aging may be involved in the deregulation of the chemokine system in aging. Dr. Yung is also investigating the effect of aging on dendritic cell function. Using a murine melanoma cancer model, he showed that `old' dendritic cells (DCs) are much less effective than their younger cohort as an immunotherapeutic agent. This is linked to the impaired ability of DCs to ingest antigen and to stimulate T cells. These findings may help to explain why elderly patients are at risk for a multitude of immune/inflammatory diseases.

Brief Biography
Dr. Raymond Yung is a professor of Internal Medicine and a research scientist at the Veterans Affairs Ann Arbor Geriatric Research, Education and Clinical Center. He obtained his medical school training from the University of Liverpool in England (1986). After completing an internal medicine residency at Sinai Hospital in Detroit, he received further clinical and research fellowship training in Rheumatology (1994) and Geriatric Medicine (1996) at the University of Michigan, where he has since remained a faculty member. Dr. Yung is a recipient of the NIH Individual National Research Service Award (1994-1996) and Clinical Investigator Award (1997-2002), and the American Federation for Aging Research Paul Beeson Physician Faculty Scholars in Aging Research Award (1998-2001). In addition, he has received the American College of Rheumatology Senior Rheumatology Scholar Award (1994). He is currently funded by the NIH in his research effort on the effects of aging on T cell chemokine function. In addition to his research endeavor, Dr. Yung is also the Director of the Musculoskeletal Sequence in the Medical School curriculum. Dr. Yung was named chief, Division of Geriatric and Palliative Medicine and co-director, Geriatrics Center in 2011.