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Jun Hee Lee, Ph.D.

Title and department:Jun Hee Lee
Assistant Professor, Molecular and Integrative Physiology
Research Assistant Professor, Institute of Gerontology

Mailing address:
University of Michigan
3019 BSRB, 109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Lab address:
University of Michigan
3358 BSRB, 109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Phone: (734)764-6789; Fax: (734) 936-9220


Links to laboratory or personal web pages:

Research Interests
We focus on diverse physiologies including growth, development and aging that are controlled by signal transduction networks. Recently, our research has revealed that Sestrin, a stress-inducible protein, is a feedback inhibitor of TOR signaling, and that loss of Sestrin can cause various chronic TOR-associated pathologies, such as fat accumulation, mitochondrial dysfunction, cardiac arrhythmia and muscle degeneration. These phenotypes are quite similar to those associated with obesity, aging and lack of exercise, which are currently some of the major public health issues facing our society. We expect that further research on mammalian Sestrin-family proteins may provide a novel way to attenuate aging and prevent or treat age-associated diseases in humans.

Brief Biography
Jun Hee Lee, Ph.D., received his Ph.D. degree in biological sciences from Korea Advanced Institute of Science and Technology (KAIST) in February 2006. After postdoctoral studies in pharmacology at University of California, San Diego from 2007-2011, he joined the faculty of University of Michigan. His laboratory works on the genetic control of aging by Sestrin-TOR signaling network.

Recent Publications
Lee, J. H., Koh, H., Kim, M., Kim, Y., Lee, S. Y., Karess, R., Lee, S., Shong, M., Kim, J., Kim, J. and Chung, J. (2007) Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature, 447, 1017-1020. PMID: 17486097

Park, E. J., Lee, J. H., Yu, G., He, G., Ali, S. R., Holzer, R. G., Osterreicher, C. H., Takahashi, H., Karin, M. (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell, 140, 197-208. PMID: 20141834, PMCID: PMC2836922

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science, 327, 1213-1218. PMID: 20203043, PMCID: PMC2866632

Sun, D., Lee, G., Lee, J. H.*, Kim, H., Rhee, H., Park, S., Kim, K., Kim, Y., Kim, B. Y., Hong, J., Park, C., Choy, H. E., Kim, J. H., Jeon, Y. H., Chung, J. (2010) A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat. Struct. Mol. Biol.17, 1188-1194. PMID: 20818390
* co-first author but listed third.

Lee, J. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrins at the crossroad between stress and aging. Aging, 2, 369-374. PMID: 20606249, PMCID: PMC2919257 (Review)