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Younger Lab Menu

Published Laboratory Research

Partial liquid ventilation protects the lung from neutrophil invasion during resuscitation from shock. Younger JG, Taqi AS, Till GO, Hirschl RB. Journal of Applied Physiology 1997; 83:1666-1670.

The pattern of early lung parenchymal and airspace injury following acute blood loss.
Younger JG, Taqi AS, Jost PF, Till GO, Johnson KJ, Stern SA, Hirschl RB
Academic Emergency Medicine 1998; 7: 659-665.

Characteristics of an albumin dialysate hemodiafiltration system for the clearance of unconjugated bilirubin
Awad S, Rich P, Kolla S, Younger JG, Reickert CA, Downing VP, Bartlett RH:
ASAIO Journal 1997; 43:M745-M749.

Systemic hemodynamic and metabolic effects of rapid intravascular activation of the complement system
Younger JG, Sasaki N, Ngheim T, Till GO, Ward PA
Proceedings of the 5th World Congress on Trauma, Shock, Inflammation, and Sepsis. Monduzzi Editore, Bologna, Italy 2000; 167-171.

Comparison of the effects of bolus versus slow infusion of 7.5% NaCl / 6% dextran-70 in a model of near-lethal uncontrolled hemorrhage
Stern SA, Kowalenko T, Younger JG, Wang X, Dronen SC
Shock 2000; 14:616-622.

Detrimental effects of complement activation in hemorrhagic shock
Younger JG, Sasaki N, Saleh E, Ravage Z, Ward PA, Till GO
Journal of Applied Physiology 2001; 90:441-446.

Reduced Syk phosphorylation accompanies decreased neutrophil chemotaxis and phagocytosis following exposure to perflubron.
Fernandez R, Sarma JV, Younkin E, Hirschl RB, Ward PA, Younger JG. J Applied Physiol.2001; 91:1941-7.

Systemic complement depletion diminishes peri-hematomal brain edema.
Xi G, Hua Y, Keep RF, Younger JG, Hoff JT
Stroke 2001; 32:162-167.

Systemic and lung physiological changes after intravascular activation of complement.
Younger JG, Sasaki N, Delgado J, Ko AC, Nghiem TX, Waite MD, Till GO, Ward PA
Journal of Applied Physiology 2001; 90:2289-95.

Protective effects of anti-C5a peptide antibodies in experimental sepsis.
Huber-Lang MS, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Younkin EM, Laudes IJ, Riedemann NC, Younger JG, Ward PA
FASEB Journal 2001; 15:568-77.

Effects of partial liquid ventilation on unilateral lung injury in dogs.
Sawada S, Matsuda K, Younger JG, Johnson KJ, Bartlett RH, Hirschl RB. Chest 2002; 121:566-72.

Brain edema after intracerebral hemorrhage: The effects of system complement depletion.
Xi G, Hua Y, Keep RF, Younger JG, Hoff JT: Acta Neurochir2002; 81 [Suppl]:253-256.

Generation of C5a by phagocytes.
Huber-Lang MS, Younkin EM, Sarma JV, Rioedemann N, Mcquire SR, Lu KT, Kunkel R, Younger JG, Zetoune FS, Ward PA. Amer J Path 2002; 161:1849-1859.

Segmental hemodynamics during partial liquid ventilation in isolated rat lungs.
Ko AC, Hirsh E, Wong AC, Moore T, Taylor AE, Hirschl RB, Younger JG. In press, Resuscitation.

Complement interactions with Pseudomonas aeruginosa and their proinflammatory consequences in vivo.
Younger JG, Shankar-Sinha S, Mickiewicz M, Brinkman AS, Sarma JV, Younkin EM, Standiford TJ, Zetoune FS, Ward PA. In press, Am J Resp Cell Mol Biol.

Inhibition of prostaglandin synthesis during experimental massive pulmonary embolism in the rat.
Jones AE, Watts JA, Debelak J, Thornton LR, Younger JG, Kline JA. In press, Amer J Physiol.

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Published Clinical Research

Relationship between arterial and peripheral venous lactate levels
Younger JG, Falk JL, Rothrock SG
Academic Emergency Medicine 1996; 3:730.

The use of extracorporeal life support for adult patients with respiratory failure and sepsis
Rich PB, Younger JG, Soldes OS, Awad SS, Bartlett RB
ASAIO Journal 1998; 44:263-266.

Extracorporeal life support (ECLS) for severe pulmonary failure following trauma
Michaels AJ, Schreiner RJ, Kolla S, Awad S, Rich P, Rieckert C, Younger JG, Hirschl R, Bartlett RH
Journal of Trauma 1999; 46: 638-645.

Extracorporeal resuscitation of cardiac arrest
Younger JG, Schreiner RJ, Hirschl RB, Chapman RA, Bartlett RH:
Academic Emergency Medicine 1999; 6:700-707. Accompanying editorial: Angelos M:
Overcoming reperfusion failure in order to treat reperfusion injury. Acad Emerg Med 1999; 6:677-678.

Delayed partial airway obstruction following blunt thyroid trauma
Blaivas M, Hom D, Younger JG
American Journal of Emergency Medicine 1999; 17:348-50.

Predictors of malignancy in childhood peripheral lymphadenopathy
Soldes OS, Younger JG, Hirsch RB
Journal of Pediatric Surgery 1999; 34:1447-1452.

The role of arrhythmias induced during dobutamine echocardiography in perioperative risk assessment
Day SM, Younger JG, Karavite D, Bach D, Armstrong W, Eagle KA
American Journal of Cardiology 2000; 85:478-483.

Extracorporeal life support: the University of Michigan experience
Bartlett RH, Roloff DW, Custer JR, Younger JG, Hirschl RB
JAMA 2000; 283:904-908.

A randomized comparison of helium-oxygen mixture and racemic epinephrine for the treatment of moderate to severe croup
Weber JE, Chudnofsky CR, Younger JG, Larkin GL, Boczar M, Wilkerson MD. Pediatrics 2001; 107:1-4.

A review of 100 patients transported on extracorporeal life support
Foley DS, Pranikoff T, Younger JG, Swaniker F, Hemmila MR, Remenapp RA, Copenhaver W, Landis D, Hirschl RB, Bartlett RH. ASAIO Journal. 48(6):612-9, 2002 Nov-Dec.

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Published Reviews, Position Statements, Chapters, and Other Work

Research Fundamentals: Receiver Operator Characteristic Curves
Grzybowski M, Younger JG
Academic Emergency Medicine 1997; 4:818-826.

Getting from hypothesis to manuscript: An overview of the skills required for success in research
Lewis LM, Lewis RJ, Younger JG, Callaham M
Academic Emergency Medicine 1998; 5:924-929.

Research fundamentals: The use of laboratory animal models in research
O’Neil BJ, Kline JA, Burkhart K, Younger JG
Academic Emergency Medicine 1999; 6:75-82.

Seminars in Respiratory and Critical Care Medicine: Managing Emergencies in Critical Care
Barsan WA, Younger JG, Guest editors. Sem Resp Crit Care Med 2002; 23.

Cerebrovascular Emergencies
Younger JG, Barsan WG
in Howell JM (eds) Emergency Medicine, 1st edition. Philadelphia, W.B. Saunders, 1997, p 799-808

Central Venous Access
Mickiewicz M, Dronen SC, Younger JG
in Roberts J, Hedges R (eds) Procedures in Emergency Medicine, 4th edition. Philadelphia, W.B. Saunders, in press.

Percutaneous Central Venous Access
Younger JG, Dronen SC
in Howell JM (ed) Emergency Medicine, 1st edition. Philadelphia, W.B. Saunders, 1997, p 61-68

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